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Clinical and Genetic Risk Factors Associated With the Presence of Lupus Nephritis
OBJECTIVE: To elucidate whether clinical features and the weighted genetic risk score (wGRS) were associated with the presence of lupus nephritis (LN) METHODS: We retrospectively divided patients with systemic lupus erythematosus (SLE, n=1,078) into biopsy-proven LN (n=507) and non-LN groups (non-LN...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean College of Rheumatology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324894/ https://www.ncbi.nlm.nih.gov/pubmed/37475996 http://dx.doi.org/10.4078/jrd.2021.28.3.150 |
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author | Shin, Jung-Min Kim, Dam Kwon, Young-Chang Ahn, Ga-Young Lee, Jiyoung Park, Youngho Lee, Yeon-Kyung Lee, Tae-Han Park, Dae Jin Song, Yeo-Jin Ha, Eunji Kim, Kwangwoo Bang, So-Young Choi, Chan-Bum Lee, Hye-Soon Bae, Sang-Cheol |
author_facet | Shin, Jung-Min Kim, Dam Kwon, Young-Chang Ahn, Ga-Young Lee, Jiyoung Park, Youngho Lee, Yeon-Kyung Lee, Tae-Han Park, Dae Jin Song, Yeo-Jin Ha, Eunji Kim, Kwangwoo Bang, So-Young Choi, Chan-Bum Lee, Hye-Soon Bae, Sang-Cheol |
author_sort | Shin, Jung-Min |
collection | PubMed |
description | OBJECTIVE: To elucidate whether clinical features and the weighted genetic risk score (wGRS) were associated with the presence of lupus nephritis (LN) METHODS: We retrospectively divided patients with systemic lupus erythematosus (SLE, n=1,078) into biopsy-proven LN (n=507) and non-LN groups (non-LN, n=571) Baseline clinical features, serologic markers, and the wGRS were collected The wGRS was calculated from 112 non-human leukocyte antigen (non-HLA) loci and HLA-DRβ1 amino acid haplotypes for SLE Associations among clinical features, wGRS, and the presence of LN were identified RESULTS: In the multivariate analysis, patients with LN were younger at diagnosis (odds ratio [OR]=0.97, p<0.001), had more pleuritis (OR=2.44, p<0.001) and pericarditis (OR=1.62, p=0.029), had a higher detection rate of anti-double stranded deoxyribonucleic acid (anti-dsDNA antibodies, OR=2.22, p<0.001), anti-Smith antibodies (anti-Sm antibodies, OR=1.70, p=0.002), low level of complement (OR=1.37, p=0.043) and absence of antiphospholipid antibodies (aPL antibodies, OR=1.60, p=0.002), and had higher wGRS (OR=1.16, p=0.012) Mediation analysis suggested that anti-Sm antibodies and low complement could be mediators in the relationship between high wGRS and the presence of LN CONCLUSION: Onset age, pleuritis, pericarditis, several serologic markers, and wGRS were associated with the presence of LN Anti-Sm antibodies and low complement appeared to mediate the indirect relationship between wGRS and the presence of LN |
format | Online Article Text |
id | pubmed-10324894 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean College of Rheumatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-103248942023-07-20 Clinical and Genetic Risk Factors Associated With the Presence of Lupus Nephritis Shin, Jung-Min Kim, Dam Kwon, Young-Chang Ahn, Ga-Young Lee, Jiyoung Park, Youngho Lee, Yeon-Kyung Lee, Tae-Han Park, Dae Jin Song, Yeo-Jin Ha, Eunji Kim, Kwangwoo Bang, So-Young Choi, Chan-Bum Lee, Hye-Soon Bae, Sang-Cheol J Rheum Dis Original Article OBJECTIVE: To elucidate whether clinical features and the weighted genetic risk score (wGRS) were associated with the presence of lupus nephritis (LN) METHODS: We retrospectively divided patients with systemic lupus erythematosus (SLE, n=1,078) into biopsy-proven LN (n=507) and non-LN groups (non-LN, n=571) Baseline clinical features, serologic markers, and the wGRS were collected The wGRS was calculated from 112 non-human leukocyte antigen (non-HLA) loci and HLA-DRβ1 amino acid haplotypes for SLE Associations among clinical features, wGRS, and the presence of LN were identified RESULTS: In the multivariate analysis, patients with LN were younger at diagnosis (odds ratio [OR]=0.97, p<0.001), had more pleuritis (OR=2.44, p<0.001) and pericarditis (OR=1.62, p=0.029), had a higher detection rate of anti-double stranded deoxyribonucleic acid (anti-dsDNA antibodies, OR=2.22, p<0.001), anti-Smith antibodies (anti-Sm antibodies, OR=1.70, p=0.002), low level of complement (OR=1.37, p=0.043) and absence of antiphospholipid antibodies (aPL antibodies, OR=1.60, p=0.002), and had higher wGRS (OR=1.16, p=0.012) Mediation analysis suggested that anti-Sm antibodies and low complement could be mediators in the relationship between high wGRS and the presence of LN CONCLUSION: Onset age, pleuritis, pericarditis, several serologic markers, and wGRS were associated with the presence of LN Anti-Sm antibodies and low complement appeared to mediate the indirect relationship between wGRS and the presence of LN Korean College of Rheumatology 2021-07-01 2021-07-01 /pmc/articles/PMC10324894/ /pubmed/37475996 http://dx.doi.org/10.4078/jrd.2021.28.3.150 Text en Copyright © 2021 by The Korean College of Rheumatology. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Shin, Jung-Min Kim, Dam Kwon, Young-Chang Ahn, Ga-Young Lee, Jiyoung Park, Youngho Lee, Yeon-Kyung Lee, Tae-Han Park, Dae Jin Song, Yeo-Jin Ha, Eunji Kim, Kwangwoo Bang, So-Young Choi, Chan-Bum Lee, Hye-Soon Bae, Sang-Cheol Clinical and Genetic Risk Factors Associated With the Presence of Lupus Nephritis |
title | Clinical and Genetic Risk Factors Associated With the Presence of Lupus Nephritis |
title_full | Clinical and Genetic Risk Factors Associated With the Presence of Lupus Nephritis |
title_fullStr | Clinical and Genetic Risk Factors Associated With the Presence of Lupus Nephritis |
title_full_unstemmed | Clinical and Genetic Risk Factors Associated With the Presence of Lupus Nephritis |
title_short | Clinical and Genetic Risk Factors Associated With the Presence of Lupus Nephritis |
title_sort | clinical and genetic risk factors associated with the presence of lupus nephritis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324894/ https://www.ncbi.nlm.nih.gov/pubmed/37475996 http://dx.doi.org/10.4078/jrd.2021.28.3.150 |
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