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Advances in Management of Intestinal Behçet’s Disease: A Perspective From Gastroenterologists
Intestinal Behçet’s disease (intestinal BD) is a rare chronic inflammatory disorder of the intestine that is characterized by recurrent intestinal manifestations with other systemic features of BD. Intestinal BD is diagnosed when a typically shaped ulcer is observed in the gastrointestinal tract, an...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean College of Rheumatology
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324954/ https://www.ncbi.nlm.nih.gov/pubmed/37476392 http://dx.doi.org/10.4078/jrd.2021.28.1.4 |
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author | Cheon, Jae Hee |
author_facet | Cheon, Jae Hee |
author_sort | Cheon, Jae Hee |
collection | PubMed |
description | Intestinal Behçet’s disease (intestinal BD) is a rare chronic inflammatory disorder of the intestine that is characterized by recurrent intestinal manifestations with other systemic features of BD. Intestinal BD is diagnosed when a typically shaped ulcer is observed in the gastrointestinal tract, and the clinical findings meet the diagnostic criteria for BD. Owing to the small number of patients, intestinal BD is easily underestimated. On the other hand, but it often requires surgical treatment because of severe complications, including intestinal perforations or massive bleeding. The same treatment strategies used for inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, are used for intestinal BD. 5-Aminosalicylic acids, corticosteroids, and immunomodulators are considered conventional therapies, but a considerable number of patients eventually become unresponsive to these pharmaceutical treatments. Recently, biologic agents, such as anti-tumor necrosis factor-alpha inhibitors, have also been suggested as a new treatment option for intestinal BD. This article reviews the pathogenesis and diagnosis of intestinal BD and the current treatment strategies that are expected to be useful for rheumatologic specialists. |
format | Online Article Text |
id | pubmed-10324954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean College of Rheumatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-103249542023-07-20 Advances in Management of Intestinal Behçet’s Disease: A Perspective From Gastroenterologists Cheon, Jae Hee J Rheum Dis Review Article Intestinal Behçet’s disease (intestinal BD) is a rare chronic inflammatory disorder of the intestine that is characterized by recurrent intestinal manifestations with other systemic features of BD. Intestinal BD is diagnosed when a typically shaped ulcer is observed in the gastrointestinal tract, and the clinical findings meet the diagnostic criteria for BD. Owing to the small number of patients, intestinal BD is easily underestimated. On the other hand, but it often requires surgical treatment because of severe complications, including intestinal perforations or massive bleeding. The same treatment strategies used for inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, are used for intestinal BD. 5-Aminosalicylic acids, corticosteroids, and immunomodulators are considered conventional therapies, but a considerable number of patients eventually become unresponsive to these pharmaceutical treatments. Recently, biologic agents, such as anti-tumor necrosis factor-alpha inhibitors, have also been suggested as a new treatment option for intestinal BD. This article reviews the pathogenesis and diagnosis of intestinal BD and the current treatment strategies that are expected to be useful for rheumatologic specialists. Korean College of Rheumatology 2021-01-01 2021-01-01 /pmc/articles/PMC10324954/ /pubmed/37476392 http://dx.doi.org/10.4078/jrd.2021.28.1.4 Text en Copyright © 2021 by The Korean College of Rheumatology. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Cheon, Jae Hee Advances in Management of Intestinal Behçet’s Disease: A Perspective From Gastroenterologists |
title | Advances in Management of Intestinal Behçet’s Disease: A Perspective From Gastroenterologists |
title_full | Advances in Management of Intestinal Behçet’s Disease: A Perspective From Gastroenterologists |
title_fullStr | Advances in Management of Intestinal Behçet’s Disease: A Perspective From Gastroenterologists |
title_full_unstemmed | Advances in Management of Intestinal Behçet’s Disease: A Perspective From Gastroenterologists |
title_short | Advances in Management of Intestinal Behçet’s Disease: A Perspective From Gastroenterologists |
title_sort | advances in management of intestinal behçet’s disease: a perspective from gastroenterologists |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324954/ https://www.ncbi.nlm.nih.gov/pubmed/37476392 http://dx.doi.org/10.4078/jrd.2021.28.1.4 |
work_keys_str_mv | AT cheonjaehee advancesinmanagementofintestinalbehcetsdiseaseaperspectivefromgastroenterologists |