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Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis

BACKGROUND: Growing evidence suggests a significant association between vitamin D deficiency and RAS. Hence, the present meta-analysis and trial sequential analysis sought to investigate the potential association between low serum vitamin D levels and RAS. METHODS: PubMed, Scopus, Embase, and Web of...

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Autores principales: Al-Maweri, Sadeq Ali, Al-Qadhi, Gamilah, Halboub, Esam, Alaizari, Nader, Almeslet, Asma, Ali, Kamran, Osman, Safa A. Azim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325032/
https://www.ncbi.nlm.nih.gov/pubmed/37426194
http://dx.doi.org/10.3389/fnut.2023.1132191
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author Al-Maweri, Sadeq Ali
Al-Qadhi, Gamilah
Halboub, Esam
Alaizari, Nader
Almeslet, Asma
Ali, Kamran
Osman, Safa A. Azim
author_facet Al-Maweri, Sadeq Ali
Al-Qadhi, Gamilah
Halboub, Esam
Alaizari, Nader
Almeslet, Asma
Ali, Kamran
Osman, Safa A. Azim
author_sort Al-Maweri, Sadeq Ali
collection PubMed
description BACKGROUND: Growing evidence suggests a significant association between vitamin D deficiency and RAS. Hence, the present meta-analysis and trial sequential analysis sought to investigate the potential association between low serum vitamin D levels and RAS. METHODS: PubMed, Scopus, Embase, and Web of Science were comprehensively searched on December 1(st), 2022 to retrieve all relevant studies. The grey literature was also searched via ProQuest. All case-control studies on the association between vitamin D and RAS were considered. The quality appraisal of the included studies was done using Newcastle-Ottawa scale. RevMan 5.0 and trial sequential analysis (TSA) programs were used for analyses. RESULTS: A total of 14 case-control studies with 1468 subjects (721 RAS patients and 747 controls) were included. The pooled data revealed a significant association between low serum levels of vitamin D and the risk of RAS (mean difference = – 8.73, 95% CI: – 12.02 to – 5.44, I(2) = 94%, P < 0.00001). Additionally, TSA findings indicated that the current studies surpassed the required information size, confirming that the differences were reliable. CONCLUSION: The available evidence suggests that Vitamin D deficiency may have a role in the pathogenesis of RAS. Therefore, evaluation of vitamin D should be considered in RAS patients. Additionally, the results support the possibility of using vitamin D supplements in the management of RAS patients with inadequate serum levels of vitamin D. Future interventional studies are required to evaluate the benefits of vitamin D replacement in prevention and treatment of RAS.
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spelling pubmed-103250322023-07-07 Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis Al-Maweri, Sadeq Ali Al-Qadhi, Gamilah Halboub, Esam Alaizari, Nader Almeslet, Asma Ali, Kamran Osman, Safa A. Azim Front Nutr Nutrition BACKGROUND: Growing evidence suggests a significant association between vitamin D deficiency and RAS. Hence, the present meta-analysis and trial sequential analysis sought to investigate the potential association between low serum vitamin D levels and RAS. METHODS: PubMed, Scopus, Embase, and Web of Science were comprehensively searched on December 1(st), 2022 to retrieve all relevant studies. The grey literature was also searched via ProQuest. All case-control studies on the association between vitamin D and RAS were considered. The quality appraisal of the included studies was done using Newcastle-Ottawa scale. RevMan 5.0 and trial sequential analysis (TSA) programs were used for analyses. RESULTS: A total of 14 case-control studies with 1468 subjects (721 RAS patients and 747 controls) were included. The pooled data revealed a significant association between low serum levels of vitamin D and the risk of RAS (mean difference = – 8.73, 95% CI: – 12.02 to – 5.44, I(2) = 94%, P < 0.00001). Additionally, TSA findings indicated that the current studies surpassed the required information size, confirming that the differences were reliable. CONCLUSION: The available evidence suggests that Vitamin D deficiency may have a role in the pathogenesis of RAS. Therefore, evaluation of vitamin D should be considered in RAS patients. Additionally, the results support the possibility of using vitamin D supplements in the management of RAS patients with inadequate serum levels of vitamin D. Future interventional studies are required to evaluate the benefits of vitamin D replacement in prevention and treatment of RAS. Frontiers Media S.A. 2023-06-22 /pmc/articles/PMC10325032/ /pubmed/37426194 http://dx.doi.org/10.3389/fnut.2023.1132191 Text en Copyright © 2023 Al-Maweri, Al-Qadhi, Halboub, Alaizari, Almeslet, Ali and Osman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Al-Maweri, Sadeq Ali
Al-Qadhi, Gamilah
Halboub, Esam
Alaizari, Nader
Almeslet, Asma
Ali, Kamran
Osman, Safa A. Azim
Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis
title Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis
title_full Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis
title_fullStr Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis
title_full_unstemmed Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis
title_short Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis
title_sort vitamin d deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325032/
https://www.ncbi.nlm.nih.gov/pubmed/37426194
http://dx.doi.org/10.3389/fnut.2023.1132191
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