Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens

Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-containing phagosomes, and Gal-3 and Gal-8 are reported...

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Detalles Bibliográficos
Autores principales: Morrison, Huntly M., Craft, Julia, Rivera-Lugo, Rafael, Johnson, Jeffery R., Golovkine, Guillaume R., Bell, Samantha L., Dodd, Claire E., Van Dis, Erik, Beatty, Wandy L., Margolis, Shally R., Repasy, Teresa, Shaker, Isaac, Lee, Angus Y., Vance, Russell E., Stanley, Sarah A., Watson, Robert O., Krogan, Nevan J., Portnoy, Daniel A., Penn, Bennett H., Cox, Jeffery S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325092/
https://www.ncbi.nlm.nih.gov/pubmed/37352334
http://dx.doi.org/10.1371/journal.ppat.1011088

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