A systematic CRISPR screen reveals redundant and specific roles for Dscam1 isoform diversity in neuronal wiring

Drosophila melanogaster Down syndrome cell adhesion molecule 1 (Dscam1) encodes 19,008 diverse ectodomain isoforms via the alternative splicing of exon 4, 6, and 9 clusters. However, whether individual isoforms or exon clusters have specific significance is unclear. Here, using phenotype–diversity c...

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Detalles Bibliográficos
Autores principales: Dong, Haiyang, Yang, Xi, Wu, Lili, Zhang, Shixin, Zhang, Jian, Guo, Pengjuan, Du, Yiwen, Pan, Changkun, Fu, Ying, Li, Lei, Shi, Jilong, Zhu, Yanda, Ma, Hongru, Bian, Lina, Xu, Bingbing, Li, Guo, Shi, Feng, Huang, Jianhua, He, Haihuai, Jin, Yongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325099/
https://www.ncbi.nlm.nih.gov/pubmed/37410725
http://dx.doi.org/10.1371/journal.pbio.3002197

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