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Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group
We formed an international research collaboration that included Japan, South Korea, Brazil, Thailand, Taiwan, the UK, and the US (682 patients from 13 hospitals between 2005 and 2020), to better evaluate the role of race, ethnicity, and other risk factors in the pathophysiology of Stevens–Johnson sy...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325566/ https://www.ncbi.nlm.nih.gov/pubmed/37425307 http://dx.doi.org/10.3389/fmed.2023.1189140 |
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author | Ueta, Mayumi Inoue, Chikara Nakata, Mitsuko Sotozono, Chie Kim, Mee Kum Wakamatsu, Tais Jongkhajornpong, Passara Saeed, Hajirah Rauz, Saaeha Ma, David Hui-Kang Yoon, Kyung Chul Puangsricharern, Vilavun Bouchard, Charles Ahmad, Sajjad Seo, Kyoung Yul Joo, Choun-Ki Gomes, Jose Alvaro Pereira Chodosh, James Kinoshita, Shigeru Teramukai, Satoshi |
author_facet | Ueta, Mayumi Inoue, Chikara Nakata, Mitsuko Sotozono, Chie Kim, Mee Kum Wakamatsu, Tais Jongkhajornpong, Passara Saeed, Hajirah Rauz, Saaeha Ma, David Hui-Kang Yoon, Kyung Chul Puangsricharern, Vilavun Bouchard, Charles Ahmad, Sajjad Seo, Kyoung Yul Joo, Choun-Ki Gomes, Jose Alvaro Pereira Chodosh, James Kinoshita, Shigeru Teramukai, Satoshi |
author_sort | Ueta, Mayumi |
collection | PubMed |
description | We formed an international research collaboration that included Japan, South Korea, Brazil, Thailand, Taiwan, the UK, and the US (682 patients from 13 hospitals between 2005 and 2020), to better evaluate the role of race, ethnicity, and other risk factors in the pathophysiology of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Ophthalmologists often see SJS/TEN patients with severe ocular complications (SOC; frequency 50% SJS/TEN patients) when the patients are referred to them in the chronic stage after the acute stage has passed. Global data were collected using a Clinical Report Form, capturing pre-onset factors, as well as acute and chronic ocular findings. Key conclusions of this retrospective observational cohort study were as follows: (1) Ingestion of cold medications [acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs)] was significantly and positively correlated with trichiasis, symblepharon, and/or conjunctivalization of the cornea in the chronic stage; (2) common cold symptoms prior to onset of SJS/TEN were significantly and positively correlated with acute conjunctivitis and ocular surface erosions in the acute stage and with trichiasis and symblepharon and/or conjunctivalization of the cornea in the chronic stage; (3) patients with SJS/TEN who presented with SOC tended to be female; (4) patients less than 30 years of age are more likely to develop SOC in the acute and chronic stages of SJS/TEN; (5) patients with acute severe conjunctivitis with ocular surface erosion and pseudomembrane formation in the acute stage are more likely to develop ocular sequelae in the chronic stage; and (6) onychopathy in the acute stage was positively correlated with ocular sequelae in the chronic stage. Our findings show that the ingestion of cold medications, common cold symptoms prior to the onset of SJS/TEN, and a young age might strongly contribute to developing the SOC of SJS/TEN. |
format | Online Article Text |
id | pubmed-10325566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103255662023-07-07 Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group Ueta, Mayumi Inoue, Chikara Nakata, Mitsuko Sotozono, Chie Kim, Mee Kum Wakamatsu, Tais Jongkhajornpong, Passara Saeed, Hajirah Rauz, Saaeha Ma, David Hui-Kang Yoon, Kyung Chul Puangsricharern, Vilavun Bouchard, Charles Ahmad, Sajjad Seo, Kyoung Yul Joo, Choun-Ki Gomes, Jose Alvaro Pereira Chodosh, James Kinoshita, Shigeru Teramukai, Satoshi Front Med (Lausanne) Medicine We formed an international research collaboration that included Japan, South Korea, Brazil, Thailand, Taiwan, the UK, and the US (682 patients from 13 hospitals between 2005 and 2020), to better evaluate the role of race, ethnicity, and other risk factors in the pathophysiology of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Ophthalmologists often see SJS/TEN patients with severe ocular complications (SOC; frequency 50% SJS/TEN patients) when the patients are referred to them in the chronic stage after the acute stage has passed. Global data were collected using a Clinical Report Form, capturing pre-onset factors, as well as acute and chronic ocular findings. Key conclusions of this retrospective observational cohort study were as follows: (1) Ingestion of cold medications [acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs)] was significantly and positively correlated with trichiasis, symblepharon, and/or conjunctivalization of the cornea in the chronic stage; (2) common cold symptoms prior to onset of SJS/TEN were significantly and positively correlated with acute conjunctivitis and ocular surface erosions in the acute stage and with trichiasis and symblepharon and/or conjunctivalization of the cornea in the chronic stage; (3) patients with SJS/TEN who presented with SOC tended to be female; (4) patients less than 30 years of age are more likely to develop SOC in the acute and chronic stages of SJS/TEN; (5) patients with acute severe conjunctivitis with ocular surface erosion and pseudomembrane formation in the acute stage are more likely to develop ocular sequelae in the chronic stage; and (6) onychopathy in the acute stage was positively correlated with ocular sequelae in the chronic stage. Our findings show that the ingestion of cold medications, common cold symptoms prior to the onset of SJS/TEN, and a young age might strongly contribute to developing the SOC of SJS/TEN. Frontiers Media S.A. 2023-06-22 /pmc/articles/PMC10325566/ /pubmed/37425307 http://dx.doi.org/10.3389/fmed.2023.1189140 Text en Copyright © 2023 Ueta, Inoue, Nakata, Sotozono, Kim, Wakamatsu, Jongkhajornpong, Saeed, Rauz, Ma, Yoon, Puangsricharern, Bouchard, Ahmad, Seo, Joo, Gomes, Chodosh, Kinoshita and Teramukai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Ueta, Mayumi Inoue, Chikara Nakata, Mitsuko Sotozono, Chie Kim, Mee Kum Wakamatsu, Tais Jongkhajornpong, Passara Saeed, Hajirah Rauz, Saaeha Ma, David Hui-Kang Yoon, Kyung Chul Puangsricharern, Vilavun Bouchard, Charles Ahmad, Sajjad Seo, Kyoung Yul Joo, Choun-Ki Gomes, Jose Alvaro Pereira Chodosh, James Kinoshita, Shigeru Teramukai, Satoshi Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group |
title | Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group |
title_full | Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group |
title_fullStr | Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group |
title_full_unstemmed | Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group |
title_short | Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group |
title_sort | severe ocular complications of sjs/ten and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325566/ https://www.ncbi.nlm.nih.gov/pubmed/37425307 http://dx.doi.org/10.3389/fmed.2023.1189140 |
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