Cargando…

Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group

We formed an international research collaboration that included Japan, South Korea, Brazil, Thailand, Taiwan, the UK, and the US (682 patients from 13 hospitals between 2005 and 2020), to better evaluate the role of race, ethnicity, and other risk factors in the pathophysiology of Stevens–Johnson sy...

Descripción completa

Detalles Bibliográficos
Autores principales: Ueta, Mayumi, Inoue, Chikara, Nakata, Mitsuko, Sotozono, Chie, Kim, Mee Kum, Wakamatsu, Tais, Jongkhajornpong, Passara, Saeed, Hajirah, Rauz, Saaeha, Ma, David Hui-Kang, Yoon, Kyung Chul, Puangsricharern, Vilavun, Bouchard, Charles, Ahmad, Sajjad, Seo, Kyoung Yul, Joo, Choun-Ki, Gomes, Jose Alvaro Pereira, Chodosh, James, Kinoshita, Shigeru, Teramukai, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325566/
https://www.ncbi.nlm.nih.gov/pubmed/37425307
http://dx.doi.org/10.3389/fmed.2023.1189140
_version_ 1785069253343313920
author Ueta, Mayumi
Inoue, Chikara
Nakata, Mitsuko
Sotozono, Chie
Kim, Mee Kum
Wakamatsu, Tais
Jongkhajornpong, Passara
Saeed, Hajirah
Rauz, Saaeha
Ma, David Hui-Kang
Yoon, Kyung Chul
Puangsricharern, Vilavun
Bouchard, Charles
Ahmad, Sajjad
Seo, Kyoung Yul
Joo, Choun-Ki
Gomes, Jose Alvaro Pereira
Chodosh, James
Kinoshita, Shigeru
Teramukai, Satoshi
author_facet Ueta, Mayumi
Inoue, Chikara
Nakata, Mitsuko
Sotozono, Chie
Kim, Mee Kum
Wakamatsu, Tais
Jongkhajornpong, Passara
Saeed, Hajirah
Rauz, Saaeha
Ma, David Hui-Kang
Yoon, Kyung Chul
Puangsricharern, Vilavun
Bouchard, Charles
Ahmad, Sajjad
Seo, Kyoung Yul
Joo, Choun-Ki
Gomes, Jose Alvaro Pereira
Chodosh, James
Kinoshita, Shigeru
Teramukai, Satoshi
author_sort Ueta, Mayumi
collection PubMed
description We formed an international research collaboration that included Japan, South Korea, Brazil, Thailand, Taiwan, the UK, and the US (682 patients from 13 hospitals between 2005 and 2020), to better evaluate the role of race, ethnicity, and other risk factors in the pathophysiology of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Ophthalmologists often see SJS/TEN patients with severe ocular complications (SOC; frequency 50% SJS/TEN patients) when the patients are referred to them in the chronic stage after the acute stage has passed. Global data were collected using a Clinical Report Form, capturing pre-onset factors, as well as acute and chronic ocular findings. Key conclusions of this retrospective observational cohort study were as follows: (1) Ingestion of cold medications [acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs)] was significantly and positively correlated with trichiasis, symblepharon, and/or conjunctivalization of the cornea in the chronic stage; (2) common cold symptoms prior to onset of SJS/TEN were significantly and positively correlated with acute conjunctivitis and ocular surface erosions in the acute stage and with trichiasis and symblepharon and/or conjunctivalization of the cornea in the chronic stage; (3) patients with SJS/TEN who presented with SOC tended to be female; (4) patients less than 30 years of age are more likely to develop SOC in the acute and chronic stages of SJS/TEN; (5) patients with acute severe conjunctivitis with ocular surface erosion and pseudomembrane formation in the acute stage are more likely to develop ocular sequelae in the chronic stage; and (6) onychopathy in the acute stage was positively correlated with ocular sequelae in the chronic stage. Our findings show that the ingestion of cold medications, common cold symptoms prior to the onset of SJS/TEN, and a young age might strongly contribute to developing the SOC of SJS/TEN.
format Online
Article
Text
id pubmed-10325566
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103255662023-07-07 Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group Ueta, Mayumi Inoue, Chikara Nakata, Mitsuko Sotozono, Chie Kim, Mee Kum Wakamatsu, Tais Jongkhajornpong, Passara Saeed, Hajirah Rauz, Saaeha Ma, David Hui-Kang Yoon, Kyung Chul Puangsricharern, Vilavun Bouchard, Charles Ahmad, Sajjad Seo, Kyoung Yul Joo, Choun-Ki Gomes, Jose Alvaro Pereira Chodosh, James Kinoshita, Shigeru Teramukai, Satoshi Front Med (Lausanne) Medicine We formed an international research collaboration that included Japan, South Korea, Brazil, Thailand, Taiwan, the UK, and the US (682 patients from 13 hospitals between 2005 and 2020), to better evaluate the role of race, ethnicity, and other risk factors in the pathophysiology of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Ophthalmologists often see SJS/TEN patients with severe ocular complications (SOC; frequency 50% SJS/TEN patients) when the patients are referred to them in the chronic stage after the acute stage has passed. Global data were collected using a Clinical Report Form, capturing pre-onset factors, as well as acute and chronic ocular findings. Key conclusions of this retrospective observational cohort study were as follows: (1) Ingestion of cold medications [acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs)] was significantly and positively correlated with trichiasis, symblepharon, and/or conjunctivalization of the cornea in the chronic stage; (2) common cold symptoms prior to onset of SJS/TEN were significantly and positively correlated with acute conjunctivitis and ocular surface erosions in the acute stage and with trichiasis and symblepharon and/or conjunctivalization of the cornea in the chronic stage; (3) patients with SJS/TEN who presented with SOC tended to be female; (4) patients less than 30 years of age are more likely to develop SOC in the acute and chronic stages of SJS/TEN; (5) patients with acute severe conjunctivitis with ocular surface erosion and pseudomembrane formation in the acute stage are more likely to develop ocular sequelae in the chronic stage; and (6) onychopathy in the acute stage was positively correlated with ocular sequelae in the chronic stage. Our findings show that the ingestion of cold medications, common cold symptoms prior to the onset of SJS/TEN, and a young age might strongly contribute to developing the SOC of SJS/TEN. Frontiers Media S.A. 2023-06-22 /pmc/articles/PMC10325566/ /pubmed/37425307 http://dx.doi.org/10.3389/fmed.2023.1189140 Text en Copyright © 2023 Ueta, Inoue, Nakata, Sotozono, Kim, Wakamatsu, Jongkhajornpong, Saeed, Rauz, Ma, Yoon, Puangsricharern, Bouchard, Ahmad, Seo, Joo, Gomes, Chodosh, Kinoshita and Teramukai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Ueta, Mayumi
Inoue, Chikara
Nakata, Mitsuko
Sotozono, Chie
Kim, Mee Kum
Wakamatsu, Tais
Jongkhajornpong, Passara
Saeed, Hajirah
Rauz, Saaeha
Ma, David Hui-Kang
Yoon, Kyung Chul
Puangsricharern, Vilavun
Bouchard, Charles
Ahmad, Sajjad
Seo, Kyoung Yul
Joo, Choun-Ki
Gomes, Jose Alvaro Pereira
Chodosh, James
Kinoshita, Shigeru
Teramukai, Satoshi
Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group
title Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group
title_full Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group
title_fullStr Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group
title_full_unstemmed Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group
title_short Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group
title_sort severe ocular complications of sjs/ten and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325566/
https://www.ncbi.nlm.nih.gov/pubmed/37425307
http://dx.doi.org/10.3389/fmed.2023.1189140
work_keys_str_mv AT uetamayumi severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT inouechikara severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT nakatamitsuko severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT sotozonochie severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT kimmeekum severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT wakamatsutais severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT jongkhajornpongpassara severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT saeedhajirah severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT rauzsaaeha severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT madavidhuikang severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT yoonkyungchul severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT puangsricharernvilavun severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT bouchardcharles severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT ahmadsajjad severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT seokyoungyul severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT joochounki severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT gomesjosealvaropereira severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT chodoshjames severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT kinoshitashigeru severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup
AT teramukaisatoshi severeocularcomplicationsofsjstenandassociationsamongpreonsetacuteandchronicfactorsareportfromtheinternationalophthalmologycollaborativegroup