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Comparative pathogenicity of BA.2.12, BA.5.2 and XBB.1 with the Delta variant in Syrian hamsters

Omicron variant is evolving into numerous sub variants with time and the information on the characteristics of these newly evolving variants are scant. Here we performed a pathogenicity evaluation of Omicron sub variants BA.2.12, BA.5.2 and XBB.1 against the Delta variant in 6–8-week-old Syrian hams...

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Autores principales: Mohandas, Sreelekshmy, Shete, Anita, Kumar, Abhimanyu, Wakchaure, Kundan, Rai, Vishal, Mote, Chandrasekhar, Dighe, Hitesh, Sarkale, Prasad, Gawande, Pranita, Yemul, Jyoti, Suryawanshi, Annasaheb, Joshi, Yash, Yadav, Pragya D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325568/
https://www.ncbi.nlm.nih.gov/pubmed/37426033
http://dx.doi.org/10.3389/fmicb.2023.1183763
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author Mohandas, Sreelekshmy
Shete, Anita
Kumar, Abhimanyu
Wakchaure, Kundan
Rai, Vishal
Mote, Chandrasekhar
Dighe, Hitesh
Sarkale, Prasad
Gawande, Pranita
Yemul, Jyoti
Suryawanshi, Annasaheb
Joshi, Yash
Yadav, Pragya D.
author_facet Mohandas, Sreelekshmy
Shete, Anita
Kumar, Abhimanyu
Wakchaure, Kundan
Rai, Vishal
Mote, Chandrasekhar
Dighe, Hitesh
Sarkale, Prasad
Gawande, Pranita
Yemul, Jyoti
Suryawanshi, Annasaheb
Joshi, Yash
Yadav, Pragya D.
author_sort Mohandas, Sreelekshmy
collection PubMed
description Omicron variant is evolving into numerous sub variants with time and the information on the characteristics of these newly evolving variants are scant. Here we performed a pathogenicity evaluation of Omicron sub variants BA.2.12, BA.5.2 and XBB.1 against the Delta variant in 6–8-week-old Syrian hamster model. Body weight change, viral load in respiratory organs by real time RT-PCR/titration, cytokine mRNA quantification and histopathological evaluation of the lungs were performed. The intranasal infection of the BA.2.12, BA.5.2 and XBB.1 variants in hamster model resulted in body weight loss/reduced weight gain, inflammatory cytokine response and interstitial pneumonia with lesser severity compared to the Delta variant infection. Among the variants studied, BA.2.12 and XBB.1 showed lesser viral shedding through the upper respiratory tract, whereas the BA.5.2 showed comparable viral RNA shedding as that of the Delta variant. The study shows that the Omicron BA.2 sub variants may show difference in disease severity and transmissibility amongst each other whereas the overall disease severity of the Omicron sub variants studied were less compared to the Delta variant. The evolving Omicron sub variants and recombinants should be monitored for their properties.
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spelling pubmed-103255682023-07-07 Comparative pathogenicity of BA.2.12, BA.5.2 and XBB.1 with the Delta variant in Syrian hamsters Mohandas, Sreelekshmy Shete, Anita Kumar, Abhimanyu Wakchaure, Kundan Rai, Vishal Mote, Chandrasekhar Dighe, Hitesh Sarkale, Prasad Gawande, Pranita Yemul, Jyoti Suryawanshi, Annasaheb Joshi, Yash Yadav, Pragya D. Front Microbiol Microbiology Omicron variant is evolving into numerous sub variants with time and the information on the characteristics of these newly evolving variants are scant. Here we performed a pathogenicity evaluation of Omicron sub variants BA.2.12, BA.5.2 and XBB.1 against the Delta variant in 6–8-week-old Syrian hamster model. Body weight change, viral load in respiratory organs by real time RT-PCR/titration, cytokine mRNA quantification and histopathological evaluation of the lungs were performed. The intranasal infection of the BA.2.12, BA.5.2 and XBB.1 variants in hamster model resulted in body weight loss/reduced weight gain, inflammatory cytokine response and interstitial pneumonia with lesser severity compared to the Delta variant infection. Among the variants studied, BA.2.12 and XBB.1 showed lesser viral shedding through the upper respiratory tract, whereas the BA.5.2 showed comparable viral RNA shedding as that of the Delta variant. The study shows that the Omicron BA.2 sub variants may show difference in disease severity and transmissibility amongst each other whereas the overall disease severity of the Omicron sub variants studied were less compared to the Delta variant. The evolving Omicron sub variants and recombinants should be monitored for their properties. Frontiers Media S.A. 2023-06-22 /pmc/articles/PMC10325568/ /pubmed/37426033 http://dx.doi.org/10.3389/fmicb.2023.1183763 Text en Copyright © 2023 Mohandas, Shete, Kumar, Wakchaure, Rai, Mote, Dighe, Sarkale, Gawande, Yemul, Suryawanshi, Joshi and Yadav. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Mohandas, Sreelekshmy
Shete, Anita
Kumar, Abhimanyu
Wakchaure, Kundan
Rai, Vishal
Mote, Chandrasekhar
Dighe, Hitesh
Sarkale, Prasad
Gawande, Pranita
Yemul, Jyoti
Suryawanshi, Annasaheb
Joshi, Yash
Yadav, Pragya D.
Comparative pathogenicity of BA.2.12, BA.5.2 and XBB.1 with the Delta variant in Syrian hamsters
title Comparative pathogenicity of BA.2.12, BA.5.2 and XBB.1 with the Delta variant in Syrian hamsters
title_full Comparative pathogenicity of BA.2.12, BA.5.2 and XBB.1 with the Delta variant in Syrian hamsters
title_fullStr Comparative pathogenicity of BA.2.12, BA.5.2 and XBB.1 with the Delta variant in Syrian hamsters
title_full_unstemmed Comparative pathogenicity of BA.2.12, BA.5.2 and XBB.1 with the Delta variant in Syrian hamsters
title_short Comparative pathogenicity of BA.2.12, BA.5.2 and XBB.1 with the Delta variant in Syrian hamsters
title_sort comparative pathogenicity of ba.2.12, ba.5.2 and xbb.1 with the delta variant in syrian hamsters
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325568/
https://www.ncbi.nlm.nih.gov/pubmed/37426033
http://dx.doi.org/10.3389/fmicb.2023.1183763
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