Development and biophysical characterization of a humanized FSH–blocking monoclonal antibody therapeutic formulated at an ultra-high concentration

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Highly concentrated antibody formulations are oftentimes required for subcutaneous, self-administered biologics. Here, we report the development of a unique formulation for our first-in-class FSH-blocking humanized antibody, MS-Hu6, which we propose to move to the clinic for osteoporosis, obesity, a...

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Detalles Bibliográficos
Autores principales: Rojekar, Satish, Pallapati, Anusha R, Gimenez-Roig, Judit, Korkmaz, Funda, Sultana, Farhath, Sant, Damini, Haeck, Clement M, Macdonald, Anne, Kim, Se-Min, Rosen, Clifford J, Barak, Orly, Meseck, Marcia, Caminis, John, Lizneva, Daria, Yuen, Tony, Zaidi, Mone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325703/
https://www.ncbi.nlm.nih.gov/pubmed/37334968
http://dx.doi.org/10.7554/eLife.88898
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