CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance

Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for autoreactivity against the diverse self-antigens display...

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Detalles Bibliográficos
Autores principales: Li, Yu, Guaman Tipan, Pablo, Selden, Hilary J, Srinivasan, Jayashree, Hale, Laura P, Ehrlich, Lauren IR
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325719/
https://www.ncbi.nlm.nih.gov/pubmed/37266571
http://dx.doi.org/10.7554/eLife.80443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325719/
https://www.ncbi.nlm.nih.gov/pubmed/37266571
http://dx.doi.org/10.7554/eLife.80443

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