The activation of GABAergic neurons in the hypothalamic tuberomammillary nucleus attenuates sevoflurane and propofol-induced anesthesia in mice

Background: The histaminergic neurons in the hypothalamic tuberomammillary nucleus (TMN) have been suggested to play a vital role in maintaining a rising state. But the neuronal types of the TMN are in debate and the role of GABAergic neurons remains unclear. Methods: In the present study, we examin...

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Autores principales: Liu, Jing, Liu, Xiao, Zhou, Wen-Yu, Gan, Jun, Wang, Jie, Zhang, Qi, Li, Jun-Liang, Shen, Zhong-Shan, Zhang, Yue-Ying, Tang, Qiong-Yao, Zhang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325722/
https://www.ncbi.nlm.nih.gov/pubmed/37426823
http://dx.doi.org/10.3389/fphar.2023.1153735
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author Liu, Jing
Liu, Xiao
Zhou, Wen-Yu
Gan, Jun
Wang, Jie
Zhang, Qi
Li, Jun-Liang
Shen, Zhong-Shan
Zhang, Yue-Ying
Tang, Qiong-Yao
Zhang, Zhe
author_facet Liu, Jing
Liu, Xiao
Zhou, Wen-Yu
Gan, Jun
Wang, Jie
Zhang, Qi
Li, Jun-Liang
Shen, Zhong-Shan
Zhang, Yue-Ying
Tang, Qiong-Yao
Zhang, Zhe
author_sort Liu, Jing
collection PubMed
description Background: The histaminergic neurons in the hypothalamic tuberomammillary nucleus (TMN) have been suggested to play a vital role in maintaining a rising state. But the neuronal types of the TMN are in debate and the role of GABAergic neurons remains unclear. Methods: In the present study, we examined the role of TMN GABAergic neurons in general anesthesia using chemogenetics and optogenetics strategies to regulate the activity of TMN GABAergic neurons. Results: The results indicated that either chemogenetic or optogenetic activation of TMN GABAergic neurons in mice decreased the effect of sevoflurane and propofol anesthesia. In contrast, inhibition of the TMN GABAergic neurons facilitates the sevoflurane anesthesia effect. Conclusion: Our results suggest that the activity of TMN GABAergic neurons produces an anti-anesthesia effect in loss of consciousness and analgesia.
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spelling pubmed-103257222023-07-07 The activation of GABAergic neurons in the hypothalamic tuberomammillary nucleus attenuates sevoflurane and propofol-induced anesthesia in mice Liu, Jing Liu, Xiao Zhou, Wen-Yu Gan, Jun Wang, Jie Zhang, Qi Li, Jun-Liang Shen, Zhong-Shan Zhang, Yue-Ying Tang, Qiong-Yao Zhang, Zhe Front Pharmacol Pharmacology Background: The histaminergic neurons in the hypothalamic tuberomammillary nucleus (TMN) have been suggested to play a vital role in maintaining a rising state. But the neuronal types of the TMN are in debate and the role of GABAergic neurons remains unclear. Methods: In the present study, we examined the role of TMN GABAergic neurons in general anesthesia using chemogenetics and optogenetics strategies to regulate the activity of TMN GABAergic neurons. Results: The results indicated that either chemogenetic or optogenetic activation of TMN GABAergic neurons in mice decreased the effect of sevoflurane and propofol anesthesia. In contrast, inhibition of the TMN GABAergic neurons facilitates the sevoflurane anesthesia effect. Conclusion: Our results suggest that the activity of TMN GABAergic neurons produces an anti-anesthesia effect in loss of consciousness and analgesia. Frontiers Media S.A. 2023-06-22 /pmc/articles/PMC10325722/ /pubmed/37426823 http://dx.doi.org/10.3389/fphar.2023.1153735 Text en Copyright © 2023 Liu, Liu, Zhou, Gan, Wang, Zhang, Li, Shen, Zhang, Tang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Liu, Jing
Liu, Xiao
Zhou, Wen-Yu
Gan, Jun
Wang, Jie
Zhang, Qi
Li, Jun-Liang
Shen, Zhong-Shan
Zhang, Yue-Ying
Tang, Qiong-Yao
Zhang, Zhe
The activation of GABAergic neurons in the hypothalamic tuberomammillary nucleus attenuates sevoflurane and propofol-induced anesthesia in mice
title The activation of GABAergic neurons in the hypothalamic tuberomammillary nucleus attenuates sevoflurane and propofol-induced anesthesia in mice
title_full The activation of GABAergic neurons in the hypothalamic tuberomammillary nucleus attenuates sevoflurane and propofol-induced anesthesia in mice
title_fullStr The activation of GABAergic neurons in the hypothalamic tuberomammillary nucleus attenuates sevoflurane and propofol-induced anesthesia in mice
title_full_unstemmed The activation of GABAergic neurons in the hypothalamic tuberomammillary nucleus attenuates sevoflurane and propofol-induced anesthesia in mice
title_short The activation of GABAergic neurons in the hypothalamic tuberomammillary nucleus attenuates sevoflurane and propofol-induced anesthesia in mice
title_sort activation of gabaergic neurons in the hypothalamic tuberomammillary nucleus attenuates sevoflurane and propofol-induced anesthesia in mice
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325722/
https://www.ncbi.nlm.nih.gov/pubmed/37426823
http://dx.doi.org/10.3389/fphar.2023.1153735
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