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Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study

BACKGROUND: Meningiomas are one of the most common intracranial tumors, and the current understanding of meningioma pathology is still incomplete. Inflammatory factors play an important role in the pathophysiology of meningioma, but the causal relationship between inflammatory factors and meningioma...

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Autores principales: Zhang, Zhiyun, Wang, Shengnan, Ren, Fei, Yang, Laiyu, Xie, Haoqun, Pan, Lin, Li, Yifan, Yu, Bingcheng, Yang, Yifan, Su, Haoyi, Chen, Youqi, Zhang, Chuyi, Chen, Hongyu, Yang, Wenzhuo, An, Nan, Bai, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325787/
https://www.ncbi.nlm.nih.gov/pubmed/37425011
http://dx.doi.org/10.3389/fnins.2023.1186312
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author Zhang, Zhiyun
Wang, Shengnan
Ren, Fei
Yang, Laiyu
Xie, Haoqun
Pan, Lin
Li, Yifan
Yu, Bingcheng
Yang, Yifan
Su, Haoyi
Chen, Youqi
Zhang, Chuyi
Chen, Hongyu
Yang, Wenzhuo
An, Nan
Bai, Yang
author_facet Zhang, Zhiyun
Wang, Shengnan
Ren, Fei
Yang, Laiyu
Xie, Haoqun
Pan, Lin
Li, Yifan
Yu, Bingcheng
Yang, Yifan
Su, Haoyi
Chen, Youqi
Zhang, Chuyi
Chen, Hongyu
Yang, Wenzhuo
An, Nan
Bai, Yang
author_sort Zhang, Zhiyun
collection PubMed
description BACKGROUND: Meningiomas are one of the most common intracranial tumors, and the current understanding of meningioma pathology is still incomplete. Inflammatory factors play an important role in the pathophysiology of meningioma, but the causal relationship between inflammatory factors and meningioma is still unclear. METHOD: Mendelian randomization (MR) is an effective statistical method for reducing bias based on whole genome sequencing data. It’s a simple but powerful framework, that uses genetics to study aspects of human biology. Modern methods of MR make the process more robust by exploiting the many genetic variants that may exist for a given hypothesis. In this paper, MR is applied to understand the causal relationship between exposure and disease outcome. RESULTS: This research presents a comprehensive MR study to study the association of genetic inflammatory cytokines with meningioma. Based on the results of our MR analysis, which examines 41 cytokines in the largest GWAS datasets available, we were able to draw the relatively more reliable conclusion that elevated levels of circulating TNF-β, CXCL1, and lower levels of IL-9 were suggestive associated with a higher risk of meningioma. Moreover, Meningiomas could cause lower levels of interleukin-16 and higher levels of CXCL10 in the blood. CONCLUSION: These findings suggest that TNF-β, CXCL1, and IL-9 play an important role in the development of meningiomas. Meningiomas also affect the expression of cytokines such as IL-16 and CXCL10. Further studies are needed to determine whether these biomarkers can be used to prevent or treat meningiomas.
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spelling pubmed-103257872023-07-07 Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study Zhang, Zhiyun Wang, Shengnan Ren, Fei Yang, Laiyu Xie, Haoqun Pan, Lin Li, Yifan Yu, Bingcheng Yang, Yifan Su, Haoyi Chen, Youqi Zhang, Chuyi Chen, Hongyu Yang, Wenzhuo An, Nan Bai, Yang Front Neurosci Neuroscience BACKGROUND: Meningiomas are one of the most common intracranial tumors, and the current understanding of meningioma pathology is still incomplete. Inflammatory factors play an important role in the pathophysiology of meningioma, but the causal relationship between inflammatory factors and meningioma is still unclear. METHOD: Mendelian randomization (MR) is an effective statistical method for reducing bias based on whole genome sequencing data. It’s a simple but powerful framework, that uses genetics to study aspects of human biology. Modern methods of MR make the process more robust by exploiting the many genetic variants that may exist for a given hypothesis. In this paper, MR is applied to understand the causal relationship between exposure and disease outcome. RESULTS: This research presents a comprehensive MR study to study the association of genetic inflammatory cytokines with meningioma. Based on the results of our MR analysis, which examines 41 cytokines in the largest GWAS datasets available, we were able to draw the relatively more reliable conclusion that elevated levels of circulating TNF-β, CXCL1, and lower levels of IL-9 were suggestive associated with a higher risk of meningioma. Moreover, Meningiomas could cause lower levels of interleukin-16 and higher levels of CXCL10 in the blood. CONCLUSION: These findings suggest that TNF-β, CXCL1, and IL-9 play an important role in the development of meningiomas. Meningiomas also affect the expression of cytokines such as IL-16 and CXCL10. Further studies are needed to determine whether these biomarkers can be used to prevent or treat meningiomas. Frontiers Media S.A. 2023-06-22 /pmc/articles/PMC10325787/ /pubmed/37425011 http://dx.doi.org/10.3389/fnins.2023.1186312 Text en Copyright © 2023 Zhang, Wang, Ren, Yang, Xie, Pan, Li, Yu, Yang, Su, Chen, Zhang, Chen, Yang, An and Bai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Zhiyun
Wang, Shengnan
Ren, Fei
Yang, Laiyu
Xie, Haoqun
Pan, Lin
Li, Yifan
Yu, Bingcheng
Yang, Yifan
Su, Haoyi
Chen, Youqi
Zhang, Chuyi
Chen, Hongyu
Yang, Wenzhuo
An, Nan
Bai, Yang
Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study
title Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study
title_full Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study
title_fullStr Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study
title_full_unstemmed Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study
title_short Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study
title_sort inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325787/
https://www.ncbi.nlm.nih.gov/pubmed/37425011
http://dx.doi.org/10.3389/fnins.2023.1186312
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