Targeted tissue delivery of RNA therapeutics using antibody–oligonucleotide conjugates (AOCs)

Although targeting TfR1 to deliver oligonucleotides to skeletal muscle has been demonstrated in rodents, effectiveness and pharmacokinetic/pharmacodynamic (PKPD) properties remained unknown in higher species. We developed antibody–oligonucleotide conjugates (AOCs) towards mice or monkeys utilizing a...

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Detalles Bibliográficos
Autores principales: Malecova, Barbora, Burke, Rob S, Cochran, Michael, Hood, Michael D, Johns, Rachel, Kovach, Philip R, Doppalapudi, Venkata R, Erdogan, Gulin, Arias, J Danny, Darimont, Beatrice, Miller, Christopher D, Huang, Hanhua, Geall, Andrew, Younis, Husam S, Levin, Arthur A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325888/
https://www.ncbi.nlm.nih.gov/pubmed/37224533
http://dx.doi.org/10.1093/nar/gkad415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325888/
https://www.ncbi.nlm.nih.gov/pubmed/37224533
http://dx.doi.org/10.1093/nar/gkad415

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