Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity

The translation initiation machinery and the ribosome orchestrate a highly dynamic scanning process to distinguish proper start codons from surrounding nucleotide sequences. Here, we performed genome-wide CRISPRi screens in human K562 cells to systematically identify modulators of the frequency of t...

Descripción completa

Detalles Bibliográficos
Autores principales: She, Richard, Luo, Jingchuan, Weissman, Jonathan S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325891/
https://www.ncbi.nlm.nih.gov/pubmed/37144468
http://dx.doi.org/10.1093/nar/gkad329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325891/
https://www.ncbi.nlm.nih.gov/pubmed/37144468
http://dx.doi.org/10.1093/nar/gkad329

Ejemplares similares