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Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity

The translation initiation machinery and the ribosome orchestrate a highly dynamic scanning process to distinguish proper start codons from surrounding nucleotide sequences. Here, we performed genome-wide CRISPRi screens in human K562 cells to systematically identify modulators of the frequency of t...

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Detalles Bibliográficos
Autores principales:	She, Richard, Luo, Jingchuan, Weissman, Jonathan S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325891/ https://www.ncbi.nlm.nih.gov/pubmed/37144468 http://dx.doi.org/10.1093/nar/gkad329

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