Whole-cell modeling of E. coli confirms that in vitro tRNA aminoacylation measurements are insufficient to support cell growth and predicts a positive feedback mechanism regulating arginine biosynthesis

In Escherichia coli, inconsistencies between in vitro tRNA aminoacylation measurements and in vivo protein synthesis demands were postulated almost 40 years ago, but have proven difficult to confirm. Whole-cell modeling can test whether a cell behaves in a physiologically correct manner when paramet...

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Detalles Bibliográficos
Autores principales: Choi, Heejo, Covert, Markus W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325894/
https://www.ncbi.nlm.nih.gov/pubmed/37224536
http://dx.doi.org/10.1093/nar/gkad435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325894/
https://www.ncbi.nlm.nih.gov/pubmed/37224536
http://dx.doi.org/10.1093/nar/gkad435

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