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A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation

DNA mismatch repair (MMR) is essential for correction of DNA replication errors. Germline mutations of the human MMR gene MLH1 are the major cause of Lynch syndrome, a heritable cancer predisposition. In the MLH1 protein, a non-conserved, intrinsically disordered region connects two conserved, catal...

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Detalles Bibliográficos
Autores principales:	Wolf, Karla, Kosinski, Jan, Gibson, Toby J, Wesch, Nicole, Dötsch, Volker, Genuardi, Maurizio, Cordisco, Emanuela Lucci, Zeuzem, Stefan, Brieger, Angela, Plotz, Guido
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325900/ https://www.ncbi.nlm.nih.gov/pubmed/37224528 http://dx.doi.org/10.1093/nar/gkad418

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