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Conformational dynamics of the RNA binding channel regulates loading and translocation of the DEAH-box helicase Prp43

The DEAH-box helicase Prp43 has essential functions in pre-mRNA splicing and ribosome biogenesis, remodeling structured RNAs. To initiate unwinding, Prp43 must first accommodate a single-stranded RNA segment into its RNA binding channel. This allows translocation of the helicase on the RNA. G-patch...

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Detalles Bibliográficos
Autores principales:	Enders, Marieke, Ficner, Ralf, Adio, Sarah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325901/ https://www.ncbi.nlm.nih.gov/pubmed/37167006 http://dx.doi.org/10.1093/nar/gkad362

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