A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression

Photodynamic therapy (PDT) ideally relies on the administration, selective accumulation and photoactivation of a photosensitizer (PS) into diseased tissues. In this context, we report a new heavy-atom-free fluorescent G-quadruplex (G4) DNA-binding PS, named DBI. We reveal by fluorescence microscopy...

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Detalles Bibliográficos
Autores principales: Deiana, Marco, Andrés Castán, José María, Josse, Pierre, Kahsay, Abraha, Sánchez, Darío Puchán, Morice, Korentin, Gillet, Natacha, Ravindranath, Ranjitha, Patel, Ankit Kumar, Sengupta, Pallabi, Obi, Ikenna, Rodriguez-Marquez, Eva, Khrouz, Lhoussain, Dumont, Elise, Abad Galán, Laura, Allain, Magali, Walker, Bright, Ahn, Hyun Seo, Maury, Olivier, Blanchard, Philippe, Le Bahers, Tangui, Öhlund, Daniel, von Hofsten, Jonas, Monnereau, Cyrille, Cabanetos, Clément, Sabouri, Nasim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325911/
https://www.ncbi.nlm.nih.gov/pubmed/37191066
http://dx.doi.org/10.1093/nar/gkad365

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