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Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe

The structure of DNA replication forks is preserved by TIMELESS (TIM) in the fork protection complex (FPC) to support seamless fork progression. While the scaffolding role of the FPC to couple the replisome activity is much appreciated, the detailed mechanism whereby inherent replication fork damage...

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Detalles Bibliográficos
Autores principales:	Patel, Jinal A, Zezelic, Camryn, Rageul, Julie, Saldanha, Joanne, Khan, Arafat, Kim, Hyungjin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325925/ https://www.ncbi.nlm.nih.gov/pubmed/37144518 http://dx.doi.org/10.1093/nar/gkad363

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