ATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury

Sepsis involves endothelial cell (EC) dysfunction, which contributes to multiple organ failure. To improve therapeutic prospects, elucidating molecular mechanisms of vascular dysfunction is of the essence. ATP-citrate lyase (ACLY) directs glucose metabolic fluxes to de novo lipogenesis by generating...

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Detalles Bibliográficos
Autores principales: Li, Ranran, Meng, Mei, Chen, Ying, Pan, Tingting, Li, Yinjiaozhi, Deng, Yunxin, Zhang, Ruyuan, Tian, Rui, Xu, Wen, Zheng, Xiangtao, Gong, Fangchen, Liu, Jie, Tang, Haiting, Ding, Xiaowei, Tang, Yaoqing, Annane, Djillali, Chen, Erzhen, Qu, Hongping, Li, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325983/
https://www.ncbi.nlm.nih.gov/pubmed/37414769
http://dx.doi.org/10.1038/s41419-023-05932-8

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