A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2

A lingering question in developmental biology has centered on how transcription factors with widespread distribution in vertebrate embryos can perform tissue-specific functions. Here, using the murine hindlimb as a model, we investigate the elusive mechanisms whereby PBX TALE homeoproteins, viewed p...

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Detalles Bibliográficos
Autores principales: Losa, Marta, Barozzi, Iros, Osterwalder, Marco, Hermosilla-Aguayo, Viviana, Morabito, Angela, Chacón, Brandon H., Zarrineh, Peyman, Girdziusaite, Ausra, Benazet, Jean Denis, Zhu, Jianjian, Mackem, Susan, Capellini, Terence D., Dickel, Diane, Bobola, Nicoletta, Zuniga, Aimée, Visel, Axel, Zeller, Rolf, Selleri, Licia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325989/
https://www.ncbi.nlm.nih.gov/pubmed/37414772
http://dx.doi.org/10.1038/s41467-023-39443-z

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