Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma

A lack of relevant genetic models and cell lines hampers our understanding of hepatoblastoma pathogenesis and the development of new therapies for this neoplasm. Here, we report an improved MYC-driven hepatoblastoma-like murine model that recapitulates the pathological features of embryonal type of...

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Detalles Bibliográficos
Autores principales: Fang, Jie, Singh, Shivendra, Cheng, Changde, Natarajan, Sivaraman, Sheppard, Heather, Abu-Zaid, Ahmed, Durbin, Adam D., Lee, Ha Won, Wu, Qiong, Steele, Jacob, Connelly, Jon P., Jin, Hongjian, Chen, Wenan, Fan, Yiping, Pruett-Miller, Shondra M., Rehg, Jerold E., Koo, Selene C., Santiago, Teresa, Emmons, Joseph, Cairo, Stefano, Wang, Ruoning, Glazer, Evan S., Murphy, Andrew J., Chen, Taosheng, Davidoff, Andrew M., Armengol, Carolina, Easton, John, Chen, Xiang, Yang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326052/
https://www.ncbi.nlm.nih.gov/pubmed/37414763
http://dx.doi.org/10.1038/s41467-023-39717-6

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