The TLR3 L412F polymorphism prevents TLR3-mediated tumor cell death induction in pediatric sarcomas

Toll-like receptor 3 (TLR3) is a pattern recognition receptor mainly known for its role in innate immune response to infection. Indeed, binding of double-stranded RNA (dsRNA) to TLR3 triggers a pro-inflammatory cascade leading to cytokine release and immune cell activation. Its anti-tumoral potentia...

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Detalles Bibliográficos
Autores principales: Bisaccia, Joseph, Meyer, Swann, Bertrand-Chapel, Adrien, Hecquet, Quentin, Barbet, Virginie, Kaniewski, Bastien, Léon, Sophie, Gadot, Nicolas, Rochet, Isabelle, Fajnorova, Iveta, Leblond, Pierre, Cordier-Bussat, Martine, Corradini, Nadège, Vasiljevic, Alexandre, Billaud, Marc, Picard, Cécile, Broutier, Laura, Gallerne, Cindy, Dutour, Aurélie, Blay, Jean-Yves, Castets, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326074/
https://www.ncbi.nlm.nih.gov/pubmed/37414800
http://dx.doi.org/10.1038/s41420-023-01513-y

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