Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products

During carcinogenesis, the microenvironment plays a fundamental role in tumor progression and resistance. This tumor microenvironment (TME) is characterized by being highly immunosuppressive in most cases, which makes it an important target for the development of new therapies. One of the most impor...

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Autores principales: Calderon, Jhon Jairo, Prieto, Karol, Lasso, Paola, Fiorentino, Susana, Barreto, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326112/
https://www.ncbi.nlm.nih.gov/pubmed/37410164
http://dx.doi.org/10.1007/s00005-023-00681-0
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author Calderon, Jhon Jairo
Prieto, Karol
Lasso, Paola
Fiorentino, Susana
Barreto, Alfonso
author_facet Calderon, Jhon Jairo
Prieto, Karol
Lasso, Paola
Fiorentino, Susana
Barreto, Alfonso
author_sort Calderon, Jhon Jairo
collection PubMed
description During carcinogenesis, the microenvironment plays a fundamental role in tumor progression and resistance. This tumor microenvironment (TME) is characterized by being highly immunosuppressive in most cases, which makes it an important target for the development of new therapies. One of the most important groups of cells that orchestrate immunosuppression in TME is myeloid-derived suppressor cells (MDSCs), which have multiple mechanisms to suppress the immune response mediated by T lymphocytes and thus protect the tumor. In this review, we will discuss the importance of modulating MDSCs as a therapeutic target and how the use of natural products, due to their multiple mechanisms of action, can be a key alternative for modulating these cells and thus improve response to therapy in cancer patients.
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spelling pubmed-103261122023-07-08 Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products Calderon, Jhon Jairo Prieto, Karol Lasso, Paola Fiorentino, Susana Barreto, Alfonso Arch Immunol Ther Exp (Warsz) Review During carcinogenesis, the microenvironment plays a fundamental role in tumor progression and resistance. This tumor microenvironment (TME) is characterized by being highly immunosuppressive in most cases, which makes it an important target for the development of new therapies. One of the most important groups of cells that orchestrate immunosuppression in TME is myeloid-derived suppressor cells (MDSCs), which have multiple mechanisms to suppress the immune response mediated by T lymphocytes and thus protect the tumor. In this review, we will discuss the importance of modulating MDSCs as a therapeutic target and how the use of natural products, due to their multiple mechanisms of action, can be a key alternative for modulating these cells and thus improve response to therapy in cancer patients. Springer International Publishing 2023-07-06 2023 /pmc/articles/PMC10326112/ /pubmed/37410164 http://dx.doi.org/10.1007/s00005-023-00681-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Calderon, Jhon Jairo
Prieto, Karol
Lasso, Paola
Fiorentino, Susana
Barreto, Alfonso
Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products
title Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products
title_full Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products
title_fullStr Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products
title_full_unstemmed Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products
title_short Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products
title_sort modulation of myeloid-derived suppressor cells in the tumor microenvironment by natural products
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326112/
https://www.ncbi.nlm.nih.gov/pubmed/37410164
http://dx.doi.org/10.1007/s00005-023-00681-0
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