Cargando…
Mortality Trends Among Patients with Rheumatoid Arthritis in Western Australia
INTRODUCTION: With scarce comparative data on mortality in Australian patients with rheumatoid arthritis (RA), we investigated temporal changes in standardized mortality rates for patients with RA using longitudinal linked population-wide health data in Western Australia (WA) over the period 1980 to...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326173/ https://www.ncbi.nlm.nih.gov/pubmed/37335433 http://dx.doi.org/10.1007/s40744-023-00562-0 |
_version_ | 1785069372922920960 |
---|---|
author | Almutairi, Khalid B. Inderjeeth, Charles A. Preen, David B. Keen, Helen I. Nossent, Johannes C. |
author_facet | Almutairi, Khalid B. Inderjeeth, Charles A. Preen, David B. Keen, Helen I. Nossent, Johannes C. |
author_sort | Almutairi, Khalid B. |
collection | PubMed |
description | INTRODUCTION: With scarce comparative data on mortality in Australian patients with rheumatoid arthritis (RA), we investigated temporal changes in standardized mortality rates for patients with RA using longitudinal linked population-wide health data in Western Australia (WA) over the period 1980 to 2015. METHODS: The study included 17,125 patients with a first-time hospital contact for RA (ICD-10-AM M05.00–M06.99 and ICD-9-AM 714.00–714.99) in the study period. Standardized mortality rate ratios (SMRRs) for the RA cohort versus the WA general population was estimated using direct age standardization. We analyzed temporal trends over with dates and causes provided by the WA Death Registry. RESULTS: During 356,069 patient-years of follow-up, a total of 8955 (52%) deaths occurred in the RA cohort. The SMRR was 2.24 (95% CI 2.15–2.34) in males and 3.09 (95% CI 3.00–3.19) in females over the study period. SMRR decreased since 2000 to 1.59 (95% CI 1.39–1.81) for the period 2011–2015. Median survival was 26.80 years (95% CI 26.30–27.30), where age and comorbidity independently increased the risk of death. The leading causes of deaths were cardiovascular diseases (26.60%), cancer (16.80%), rheumatic diseases (5.80%), chronic pulmonary disease 491 (5.50%), dementia (3.00%), and diabetes 235 (2.6%). CONCLUSIONS: The mortality rate in patients with RA in WA has decreased but remains 1.59-times higher than in community counterparts, suggesting that there is room for further improvement. Comorbidity is the main modifiable risk factor to further reduce mortality in patients with RA. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40744-023-00562-0. |
format | Online Article Text |
id | pubmed-10326173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-103261732023-07-08 Mortality Trends Among Patients with Rheumatoid Arthritis in Western Australia Almutairi, Khalid B. Inderjeeth, Charles A. Preen, David B. Keen, Helen I. Nossent, Johannes C. Rheumatol Ther Original Research INTRODUCTION: With scarce comparative data on mortality in Australian patients with rheumatoid arthritis (RA), we investigated temporal changes in standardized mortality rates for patients with RA using longitudinal linked population-wide health data in Western Australia (WA) over the period 1980 to 2015. METHODS: The study included 17,125 patients with a first-time hospital contact for RA (ICD-10-AM M05.00–M06.99 and ICD-9-AM 714.00–714.99) in the study period. Standardized mortality rate ratios (SMRRs) for the RA cohort versus the WA general population was estimated using direct age standardization. We analyzed temporal trends over with dates and causes provided by the WA Death Registry. RESULTS: During 356,069 patient-years of follow-up, a total of 8955 (52%) deaths occurred in the RA cohort. The SMRR was 2.24 (95% CI 2.15–2.34) in males and 3.09 (95% CI 3.00–3.19) in females over the study period. SMRR decreased since 2000 to 1.59 (95% CI 1.39–1.81) for the period 2011–2015. Median survival was 26.80 years (95% CI 26.30–27.30), where age and comorbidity independently increased the risk of death. The leading causes of deaths were cardiovascular diseases (26.60%), cancer (16.80%), rheumatic diseases (5.80%), chronic pulmonary disease 491 (5.50%), dementia (3.00%), and diabetes 235 (2.6%). CONCLUSIONS: The mortality rate in patients with RA in WA has decreased but remains 1.59-times higher than in community counterparts, suggesting that there is room for further improvement. Comorbidity is the main modifiable risk factor to further reduce mortality in patients with RA. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40744-023-00562-0. Springer Healthcare 2023-06-19 /pmc/articles/PMC10326173/ /pubmed/37335433 http://dx.doi.org/10.1007/s40744-023-00562-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Almutairi, Khalid B. Inderjeeth, Charles A. Preen, David B. Keen, Helen I. Nossent, Johannes C. Mortality Trends Among Patients with Rheumatoid Arthritis in Western Australia |
title | Mortality Trends Among Patients with Rheumatoid Arthritis in Western Australia |
title_full | Mortality Trends Among Patients with Rheumatoid Arthritis in Western Australia |
title_fullStr | Mortality Trends Among Patients with Rheumatoid Arthritis in Western Australia |
title_full_unstemmed | Mortality Trends Among Patients with Rheumatoid Arthritis in Western Australia |
title_short | Mortality Trends Among Patients with Rheumatoid Arthritis in Western Australia |
title_sort | mortality trends among patients with rheumatoid arthritis in western australia |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326173/ https://www.ncbi.nlm.nih.gov/pubmed/37335433 http://dx.doi.org/10.1007/s40744-023-00562-0 |
work_keys_str_mv | AT almutairikhalidb mortalitytrendsamongpatientswithrheumatoidarthritisinwesternaustralia AT inderjeethcharlesa mortalitytrendsamongpatientswithrheumatoidarthritisinwesternaustralia AT preendavidb mortalitytrendsamongpatientswithrheumatoidarthritisinwesternaustralia AT keenheleni mortalitytrendsamongpatientswithrheumatoidarthritisinwesternaustralia AT nossentjohannesc mortalitytrendsamongpatientswithrheumatoidarthritisinwesternaustralia |