New halimane and clerodane diterpenoids from Croton cnidophyllus

Three new halimane furanoditerpenoids (1–3) and three new clerodane furanoditerpenoids (4–6), along with seven known terpenoids including four pimarane diterpenoids (7–10) and three norisoprenoids (11–13) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structure...

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Autores principales: Wei, Xun, Huang, Jia-Luo, Gao, Hua-Hua, Yuan, Fang-Yu, Tang, Gui-Hua, Yin, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
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Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326188/
https://www.ncbi.nlm.nih.gov/pubmed/37410272
http://dx.doi.org/10.1007/s13659-023-00386-z
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author Wei, Xun
Huang, Jia-Luo
Gao, Hua-Hua
Yuan, Fang-Yu
Tang, Gui-Hua
Yin, Sheng
author_facet Wei, Xun
Huang, Jia-Luo
Gao, Hua-Hua
Yuan, Fang-Yu
Tang, Gui-Hua
Yin, Sheng
author_sort Wei, Xun
collection PubMed
description Three new halimane furanoditerpenoids (1–3) and three new clerodane furanoditerpenoids (4–6), along with seven known terpenoids including four pimarane diterpenoids (7–10) and three norisoprenoids (11–13) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structures including absolute configuration of new furanoditerpenoids (1–6) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (8 and 9) possessed certain inhibitory effects against NO production stimulated by LPS, with IC(50) values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00386-z.
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spelling pubmed-103261882023-07-08 New halimane and clerodane diterpenoids from Croton cnidophyllus Wei, Xun Huang, Jia-Luo Gao, Hua-Hua Yuan, Fang-Yu Tang, Gui-Hua Yin, Sheng Nat Prod Bioprospect Original Article Three new halimane furanoditerpenoids (1–3) and three new clerodane furanoditerpenoids (4–6), along with seven known terpenoids including four pimarane diterpenoids (7–10) and three norisoprenoids (11–13) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structures including absolute configuration of new furanoditerpenoids (1–6) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (8 and 9) possessed certain inhibitory effects against NO production stimulated by LPS, with IC(50) values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00386-z. Springer Nature Singapore 2023-07-06 /pmc/articles/PMC10326188/ /pubmed/37410272 http://dx.doi.org/10.1007/s13659-023-00386-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Wei, Xun
Huang, Jia-Luo
Gao, Hua-Hua
Yuan, Fang-Yu
Tang, Gui-Hua
Yin, Sheng
New halimane and clerodane diterpenoids from Croton cnidophyllus
title New halimane and clerodane diterpenoids from Croton cnidophyllus
title_full New halimane and clerodane diterpenoids from Croton cnidophyllus
title_fullStr New halimane and clerodane diterpenoids from Croton cnidophyllus
title_full_unstemmed New halimane and clerodane diterpenoids from Croton cnidophyllus
title_short New halimane and clerodane diterpenoids from Croton cnidophyllus
title_sort new halimane and clerodane diterpenoids from croton cnidophyllus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326188/
https://www.ncbi.nlm.nih.gov/pubmed/37410272
http://dx.doi.org/10.1007/s13659-023-00386-z
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