Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis

The mechanisms underlying autophagic defects in nonalcoholic steatohepatitis (NASH) remain largely unknown. We aimed to elucidate the roles of hepatic cyclooxygenase 1 (COX1) in autophagy and the pathogenesis of diet-induced steatohepatitis in mice. Human nonalcoholic fatty liver disease (NAFLD) liv...

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Detalles Bibliográficos
Autores principales: Yu, Qian, Li, Chang, Niu, Qinghui, Wang, Jigang, Che, Zhaodi, Lei, Ke, Ren, He, Ma, Boyi, Ren, Yixing, Luo, Pingping, Fan, Zhuming, Zhang, Huan, Liu, Zhaohui, Tipoe, George L., Xiao, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326296/
https://www.ncbi.nlm.nih.gov/pubmed/37425048
http://dx.doi.org/10.1016/j.apsb.2023.03.008

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