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Anti-inflammatory and arthritic activity of zaltoprofen compared to piroxicam in murine models
Zaltoprofen, a unique propionic acid group of NSAIDs, works by blocking the enhancing effects of bradykinin along with the COX-2 enzyme. Therefore, it is of interest to evaluate the acute and chronic anti-inflammatory (arthritic) potential of zaltoprofen versus piroxicam in Murine models. A total of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Biomedical Informatics
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326333/ https://www.ncbi.nlm.nih.gov/pubmed/37426507 http://dx.doi.org/10.6026/97320630018752 |
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author | Sadasivam, Balakrishnan Jhaj, Ratinder Kumar, Saman Pathan, Saman Chenchula, Santenna |
author_facet | Sadasivam, Balakrishnan Jhaj, Ratinder Kumar, Saman Pathan, Saman Chenchula, Santenna |
author_sort | Sadasivam, Balakrishnan |
collection | PubMed |
description | Zaltoprofen, a unique propionic acid group of NSAIDs, works by blocking the enhancing effects of bradykinin along with the COX-2 enzyme. Therefore, it is of interest to evaluate the acute and chronic anti-inflammatory (arthritic) potential of zaltoprofen versus piroxicam in Murine models. A total of 48 Wister rats (200-250 g) of either sex (24 in each model) were used in the present study. The anti-inflammatory and arthritic potential of zaltoprofen was evaluated and compared by Carrageenan-induced acute inflammation and formalin-induced chronic inflammation. There was a significant inhibition of paw volume (P<0.001) on different time scales with two different doses of the test compound (Zaltoprofen 10 & 20 mg/kg) in the acute inflammation model compared to the negative control (NaCl 10 ml/kg). However, in the chronic inflammation model, zaltoprofen 10 mg/kg and 20 mg/kg doses of the test compound showed a significant reduction in chronic inflammation, comparable to the negative control (NaCl 10 ml/kg), although the potency was lower than the positive control (piroxicam 10 mg/kg) (P 0.05). Thus, zaltoprofen shows significant anti-inflammatory and arthritic effects in both acute and chronic models by inhibiting various inflammatory mediators. |
format | Online Article Text |
id | pubmed-10326333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-103263332023-07-08 Anti-inflammatory and arthritic activity of zaltoprofen compared to piroxicam in murine models Sadasivam, Balakrishnan Jhaj, Ratinder Kumar, Saman Pathan, Saman Chenchula, Santenna Bioinformation Research Article Zaltoprofen, a unique propionic acid group of NSAIDs, works by blocking the enhancing effects of bradykinin along with the COX-2 enzyme. Therefore, it is of interest to evaluate the acute and chronic anti-inflammatory (arthritic) potential of zaltoprofen versus piroxicam in Murine models. A total of 48 Wister rats (200-250 g) of either sex (24 in each model) were used in the present study. The anti-inflammatory and arthritic potential of zaltoprofen was evaluated and compared by Carrageenan-induced acute inflammation and formalin-induced chronic inflammation. There was a significant inhibition of paw volume (P<0.001) on different time scales with two different doses of the test compound (Zaltoprofen 10 & 20 mg/kg) in the acute inflammation model compared to the negative control (NaCl 10 ml/kg). However, in the chronic inflammation model, zaltoprofen 10 mg/kg and 20 mg/kg doses of the test compound showed a significant reduction in chronic inflammation, comparable to the negative control (NaCl 10 ml/kg), although the potency was lower than the positive control (piroxicam 10 mg/kg) (P 0.05). Thus, zaltoprofen shows significant anti-inflammatory and arthritic effects in both acute and chronic models by inhibiting various inflammatory mediators. Biomedical Informatics 2022-09-30 /pmc/articles/PMC10326333/ /pubmed/37426507 http://dx.doi.org/10.6026/97320630018752 Text en © 2022 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Research Article Sadasivam, Balakrishnan Jhaj, Ratinder Kumar, Saman Pathan, Saman Chenchula, Santenna Anti-inflammatory and arthritic activity of zaltoprofen compared to piroxicam in murine models |
title | Anti-inflammatory and arthritic activity of zaltoprofen compared to piroxicam in murine models |
title_full | Anti-inflammatory and arthritic activity of zaltoprofen compared to piroxicam in murine models |
title_fullStr | Anti-inflammatory and arthritic activity of zaltoprofen compared to piroxicam in murine models |
title_full_unstemmed | Anti-inflammatory and arthritic activity of zaltoprofen compared to piroxicam in murine models |
title_short | Anti-inflammatory and arthritic activity of zaltoprofen compared to piroxicam in murine models |
title_sort | anti-inflammatory and arthritic activity of zaltoprofen compared to piroxicam in murine models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326333/ https://www.ncbi.nlm.nih.gov/pubmed/37426507 http://dx.doi.org/10.6026/97320630018752 |
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