Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatch repair (MMR) variants

BACKGROUND: To achieve replicative immortality, most cancers develop a telomere maintenance mechanism, such as reactivation of telomerase or alternative lengthening of telomeres (ALT). There are limited data on the prevalence and clinical significance of ALT in pediatric brain tumors, and ALT-direct...

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Detalles Bibliográficos
Autores principales: Stundon, Jennifer L, Ijaz, Heba, Gaonkar, Krutika S, Kaufman, Rebecca S, Jin, Run, Karras, Anastasios, Vaksman, Zalman, Kim, Jung, Corbett, Ryan J, Lueder, Matthew R, Miller, Daniel P, Guo, Yiran, Santi, Mariarita, Li, Marilyn, Lopez, Gonzalo, Storm, Phillip B, Resnick, Adam C, Waanders, Angela J, MacFarland, Suzanne P, Stewart, Douglas R, Diskin, Sharon J, Rokita, Jo Lynne, Cole, Kristina A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Pediatric Neuro-Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326481/
https://www.ncbi.nlm.nih.gov/pubmed/36541551
http://dx.doi.org/10.1093/neuonc/noac278

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