A review on the role of CASC11 in cancers

The long non-coding RNA (lncRNA) cancer susceptibility 11 (CASC11) is a newly identified lncRNA located on chromosome 8q24.21. The expression of lncRNA CASC11 has been found to be elevated in different cancer types and the prognosis of the tumor is inversely correlated with the high CASC11 expressio...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghafouri-Fard, Soudeh, Harsij, Atefeh, Hussen, Bashdar Mahmud, Taheri, Mohammad, Sharifi, Guive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326515/
https://www.ncbi.nlm.nih.gov/pubmed/37427385
http://dx.doi.org/10.3389/fcell.2023.1131199
_version_ 1785069444001693696
author Ghafouri-Fard, Soudeh
Harsij, Atefeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Sharifi, Guive
author_facet Ghafouri-Fard, Soudeh
Harsij, Atefeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Sharifi, Guive
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description The long non-coding RNA (lncRNA) cancer susceptibility 11 (CASC11) is a newly identified lncRNA located on chromosome 8q24.21. The expression of lncRNA CASC11 has been found to be elevated in different cancer types and the prognosis of the tumor is inversely correlated with the high CASC11 expression. Moreover, lncRNA CASC11 has an oncogenic function in cancers. The biological characteristics of the tumors, such as proliferation, migration, invasion, autophagy, and apoptosis can be controlled by this lncRNA. In addition to interacting with miRNAs, proteins, transcription factors, and other molecules, the lncRNA CASC11 modulates signaling pathways including Wnt/β-catenin and epithelial-mesenchymal transition. In this review, we have summarized studies on the role of lncRNA CASC11 in the carcinogenesis from cell lines, in vivo, and clinical perspectives.
format Online
Article
Text
id pubmed-10326515
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103265152023-07-08 A review on the role of CASC11 in cancers Ghafouri-Fard, Soudeh Harsij, Atefeh Hussen, Bashdar Mahmud Taheri, Mohammad Sharifi, Guive Front Cell Dev Biol Cell and Developmental Biology The long non-coding RNA (lncRNA) cancer susceptibility 11 (CASC11) is a newly identified lncRNA located on chromosome 8q24.21. The expression of lncRNA CASC11 has been found to be elevated in different cancer types and the prognosis of the tumor is inversely correlated with the high CASC11 expression. Moreover, lncRNA CASC11 has an oncogenic function in cancers. The biological characteristics of the tumors, such as proliferation, migration, invasion, autophagy, and apoptosis can be controlled by this lncRNA. In addition to interacting with miRNAs, proteins, transcription factors, and other molecules, the lncRNA CASC11 modulates signaling pathways including Wnt/β-catenin and epithelial-mesenchymal transition. In this review, we have summarized studies on the role of lncRNA CASC11 in the carcinogenesis from cell lines, in vivo, and clinical perspectives. Frontiers Media S.A. 2023-06-23 /pmc/articles/PMC10326515/ /pubmed/37427385 http://dx.doi.org/10.3389/fcell.2023.1131199 Text en Copyright © 2023 Ghafouri-Fard, Harsij, Hussen, Taheri and Sharifi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ghafouri-Fard, Soudeh
Harsij, Atefeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Sharifi, Guive
A review on the role of CASC11 in cancers
title A review on the role of CASC11 in cancers
title_full A review on the role of CASC11 in cancers
title_fullStr A review on the role of CASC11 in cancers
title_full_unstemmed A review on the role of CASC11 in cancers
title_short A review on the role of CASC11 in cancers
title_sort review on the role of casc11 in cancers
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326515/
https://www.ncbi.nlm.nih.gov/pubmed/37427385
http://dx.doi.org/10.3389/fcell.2023.1131199
work_keys_str_mv AT ghafourifardsoudeh areviewontheroleofcasc11incancers
AT harsijatefeh areviewontheroleofcasc11incancers
AT hussenbashdarmahmud areviewontheroleofcasc11incancers
AT taherimohammad areviewontheroleofcasc11incancers
AT sharifiguive areviewontheroleofcasc11incancers
AT ghafourifardsoudeh reviewontheroleofcasc11incancers
AT harsijatefeh reviewontheroleofcasc11incancers
AT hussenbashdarmahmud reviewontheroleofcasc11incancers
AT taherimohammad reviewontheroleofcasc11incancers
AT sharifiguive reviewontheroleofcasc11incancers

Ejemplares similares