A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Pediatric high-grade gliomas (pHGG) are lethal, incurable brain tumors frequently driven by clonal mutations in histone genes. They often harbor a range of additional genetic alterations that correlate with different ages, anatomic locations, and tumor subtypes. We developed models representing 16 p...

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Detalles Bibliográficos
Autores principales: McNicholas, Michael, De Cola, Antonella, Bashardanesh, Zahedeh, Foss, Amelia, Lloyd, Cameron B., Hébert, Steven, Faury, Damien, Andrade, Augusto Faria, Jabado, Nada, Kleinman, Claudia L., Pathania, Manav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326601/
https://www.ncbi.nlm.nih.gov/pubmed/37011011
http://dx.doi.org/10.1158/2159-8290.CD-23-0004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326601/
https://www.ncbi.nlm.nih.gov/pubmed/37011011
http://dx.doi.org/10.1158/2159-8290.CD-23-0004

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