An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression

TP53 is the most frequently mutated gene in cancer, yet key target genes for p53-mediated tumor suppression remain unidentified. Here, we characterize a rare, African-specific germline variant of TP53 in the DNA-binding domain Tyr107His (Y107H). Nuclear magnetic resonance and crystal structures reve...

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Detalles Bibliográficos
Autores principales: Indeglia, Alexandra, Leung, Jessica C., Miller, Sven A., Leu, Julia I-Ju, Dougherty, James F., Clarke, Nicole L., Kirven, Nicole A., Shao, Chunlei, Ke, Lei, Lovell, Scott, Barnoud, Thibaut, Lu, David Y., Lin, Cindy, Kannan, Toshitha, Battaile, Kevin P., Yang, Tyler Hong Loong, Batista Oliva, Isabela, Claiborne, Daniel T., Vogel, Peter, Liu, Lijun, Liu, Qin, Nefedova, Yulia, Cassel, Joel, Auslander, Noam, Kossenkov, Andrew V., Karanicolas, John, Murphy, Maureen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326602/
https://www.ncbi.nlm.nih.gov/pubmed/37140445
http://dx.doi.org/10.1158/2159-8290.CD-22-1315

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