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Long noncoding RNAs, glucose metabolism and cancer (Review)

Cancer is a serious and potentially life-threatening disease, which, despite numerous advances over several decades, remains a challenge to treat that challenging to detect at an early stage or treat during the later stages. Long noncoding RNAs are >200 nucleotides long and do not possess protein...

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Autores principales: Hou, Xin-Rui, Zhang, Zhen-Dong, Cao, Xiao-Lan, Wang, Xiao-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326653/
https://www.ncbi.nlm.nih.gov/pubmed/37427347
http://dx.doi.org/10.3892/ol.2023.13925
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author Hou, Xin-Rui
Zhang, Zhen-Dong
Cao, Xiao-Lan
Wang, Xiao-Ping
author_facet Hou, Xin-Rui
Zhang, Zhen-Dong
Cao, Xiao-Lan
Wang, Xiao-Ping
author_sort Hou, Xin-Rui
collection PubMed
description Cancer is a serious and potentially life-threatening disease, which, despite numerous advances over several decades, remains a challenge to treat that challenging to detect at an early stage or treat during the later stages. Long noncoding RNAs are >200 nucleotides long and do not possess protein-coding capacity, instead regulating cellular processes, such as proliferation, differentiation, maturation, apoptosis, metastasis, and sugar metabolism. Several studies have shown the role of lncRNAs and glucose metabolism in regulating several key glycolytic enzymes and the activity of multiple functional signaling pathways during tumor progression. Thus, it is possible to further learn about the effects of lncRNA and glycolytic metabolism on tumor diagnosis, treatment, and prognosis through a thorough investigation of the lncRNA expression profiles and glycolytic metabolism in tumors. This may provide a novel strategy for improving the management of several types of cancer.
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spelling pubmed-103266532023-07-08 Long noncoding RNAs, glucose metabolism and cancer (Review) Hou, Xin-Rui Zhang, Zhen-Dong Cao, Xiao-Lan Wang, Xiao-Ping Oncol Lett Review Cancer is a serious and potentially life-threatening disease, which, despite numerous advances over several decades, remains a challenge to treat that challenging to detect at an early stage or treat during the later stages. Long noncoding RNAs are >200 nucleotides long and do not possess protein-coding capacity, instead regulating cellular processes, such as proliferation, differentiation, maturation, apoptosis, metastasis, and sugar metabolism. Several studies have shown the role of lncRNAs and glucose metabolism in regulating several key glycolytic enzymes and the activity of multiple functional signaling pathways during tumor progression. Thus, it is possible to further learn about the effects of lncRNA and glycolytic metabolism on tumor diagnosis, treatment, and prognosis through a thorough investigation of the lncRNA expression profiles and glycolytic metabolism in tumors. This may provide a novel strategy for improving the management of several types of cancer. D.A. Spandidos 2023-06-22 /pmc/articles/PMC10326653/ /pubmed/37427347 http://dx.doi.org/10.3892/ol.2023.13925 Text en Copyright: © Hou et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Hou, Xin-Rui
Zhang, Zhen-Dong
Cao, Xiao-Lan
Wang, Xiao-Ping
Long noncoding RNAs, glucose metabolism and cancer (Review)
title Long noncoding RNAs, glucose metabolism and cancer (Review)
title_full Long noncoding RNAs, glucose metabolism and cancer (Review)
title_fullStr Long noncoding RNAs, glucose metabolism and cancer (Review)
title_full_unstemmed Long noncoding RNAs, glucose metabolism and cancer (Review)
title_short Long noncoding RNAs, glucose metabolism and cancer (Review)
title_sort long noncoding rnas, glucose metabolism and cancer (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326653/
https://www.ncbi.nlm.nih.gov/pubmed/37427347
http://dx.doi.org/10.3892/ol.2023.13925
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