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Polymeric Microarray Patches for Enhanced Transdermal Delivery of the Poorly Soluble Drug Olanzapine
[Image: see text] Transdermal drug delivery is an alternative route of administration that offers avoidance of the associated drawbacks of orally and parenterally administered hydrophobics. However, owing to the extremely specific set of physicochemical characteristics required for passive transderm...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326804/ https://www.ncbi.nlm.nih.gov/pubmed/37349320 http://dx.doi.org/10.1021/acsami.3c05553 |
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author | McKenna, Peter E. Abbate, Marco T. A. Vora, Lalit K. Sabri, Akmal H. Peng, Ke Volpe-Zanutto, Fabiana Tekko, Ismaiel A. Permana, Andi Dian Maguire, Cian Dineen, David Kearney, Mary-Carmel Larrañeta, Eneko Paredes, Alejandro J. Donnelly, Ryan F. |
author_facet | McKenna, Peter E. Abbate, Marco T. A. Vora, Lalit K. Sabri, Akmal H. Peng, Ke Volpe-Zanutto, Fabiana Tekko, Ismaiel A. Permana, Andi Dian Maguire, Cian Dineen, David Kearney, Mary-Carmel Larrañeta, Eneko Paredes, Alejandro J. Donnelly, Ryan F. |
author_sort | McKenna, Peter E. |
collection | PubMed |
description | [Image: see text] Transdermal drug delivery is an alternative route of administration that offers avoidance of the associated drawbacks of orally and parenterally administered hydrophobics. However, owing to the extremely specific set of physicochemical characteristics required for passive transdermal drug permeation, the development of marketed transdermal products containing poorly soluble drugs has been severely limited. Microarray patches (MAPs) are a type of transdermal patch that differ from the traditional patch design due to the presence of tiny, micron-sized needles that permit enhanced drug permeation on their application surface. To date, MAPs have predominantly been used to deliver hydrophilic compounds. However, this work challenges this trend and focuses on the use of MAPs, in combination with commonly utilized solubility-enhancing techniques, to deliver the hydrophobic drug olanzapine (OLP) across the skin. Specifically, cyclodextrin (CD) complexation and particle size reduction were employed in tandem with hydrogel-forming and dissolving MAPs, respectively. In vivo experimentation using a female Sprague-Dawley rat model confirmed the successful delivery of OLP from hydrogel-forming MAPs (C(max) = 611.13 ± 153.34 ng/mL, T(max) = 2 h) and dissolving MAPs (C(max) = 690.56 ± 161.33 ng/mL, T(max) = 2 h) in a manner similar to that of oral therapy in terms of the rate and extent of drug absorption, as well as overall drug exposure and bioavailability. This work is the first reported use of polymeric MAPs in combination with the solubility-enhancing techniques of CD complexation and particle size reduction to successfully deliver the poorly soluble drug OLP via the transdermal route. Accordingly, this paper provides significant evidence to support an expansion of the library of molecules amenable to MAP-mediated drug delivery to include those that exhibit poor aqueous solubility. |
format | Online Article Text |
id | pubmed-10326804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-103268042023-07-08 Polymeric Microarray Patches for Enhanced Transdermal Delivery of the Poorly Soluble Drug Olanzapine McKenna, Peter E. Abbate, Marco T. A. Vora, Lalit K. Sabri, Akmal H. Peng, Ke Volpe-Zanutto, Fabiana Tekko, Ismaiel A. Permana, Andi Dian Maguire, Cian Dineen, David Kearney, Mary-Carmel Larrañeta, Eneko Paredes, Alejandro J. Donnelly, Ryan F. ACS Appl Mater Interfaces [Image: see text] Transdermal drug delivery is an alternative route of administration that offers avoidance of the associated drawbacks of orally and parenterally administered hydrophobics. However, owing to the extremely specific set of physicochemical characteristics required for passive transdermal drug permeation, the development of marketed transdermal products containing poorly soluble drugs has been severely limited. Microarray patches (MAPs) are a type of transdermal patch that differ from the traditional patch design due to the presence of tiny, micron-sized needles that permit enhanced drug permeation on their application surface. To date, MAPs have predominantly been used to deliver hydrophilic compounds. However, this work challenges this trend and focuses on the use of MAPs, in combination with commonly utilized solubility-enhancing techniques, to deliver the hydrophobic drug olanzapine (OLP) across the skin. Specifically, cyclodextrin (CD) complexation and particle size reduction were employed in tandem with hydrogel-forming and dissolving MAPs, respectively. In vivo experimentation using a female Sprague-Dawley rat model confirmed the successful delivery of OLP from hydrogel-forming MAPs (C(max) = 611.13 ± 153.34 ng/mL, T(max) = 2 h) and dissolving MAPs (C(max) = 690.56 ± 161.33 ng/mL, T(max) = 2 h) in a manner similar to that of oral therapy in terms of the rate and extent of drug absorption, as well as overall drug exposure and bioavailability. This work is the first reported use of polymeric MAPs in combination with the solubility-enhancing techniques of CD complexation and particle size reduction to successfully deliver the poorly soluble drug OLP via the transdermal route. Accordingly, this paper provides significant evidence to support an expansion of the library of molecules amenable to MAP-mediated drug delivery to include those that exhibit poor aqueous solubility. American Chemical Society 2023-06-22 /pmc/articles/PMC10326804/ /pubmed/37349320 http://dx.doi.org/10.1021/acsami.3c05553 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | McKenna, Peter E. Abbate, Marco T. A. Vora, Lalit K. Sabri, Akmal H. Peng, Ke Volpe-Zanutto, Fabiana Tekko, Ismaiel A. Permana, Andi Dian Maguire, Cian Dineen, David Kearney, Mary-Carmel Larrañeta, Eneko Paredes, Alejandro J. Donnelly, Ryan F. Polymeric Microarray Patches for Enhanced Transdermal Delivery of the Poorly Soluble Drug Olanzapine |
title | Polymeric Microarray
Patches for Enhanced Transdermal
Delivery of the Poorly Soluble Drug Olanzapine |
title_full | Polymeric Microarray
Patches for Enhanced Transdermal
Delivery of the Poorly Soluble Drug Olanzapine |
title_fullStr | Polymeric Microarray
Patches for Enhanced Transdermal
Delivery of the Poorly Soluble Drug Olanzapine |
title_full_unstemmed | Polymeric Microarray
Patches for Enhanced Transdermal
Delivery of the Poorly Soluble Drug Olanzapine |
title_short | Polymeric Microarray
Patches for Enhanced Transdermal
Delivery of the Poorly Soluble Drug Olanzapine |
title_sort | polymeric microarray
patches for enhanced transdermal
delivery of the poorly soluble drug olanzapine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326804/ https://www.ncbi.nlm.nih.gov/pubmed/37349320 http://dx.doi.org/10.1021/acsami.3c05553 |
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