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Engineering considerations of iPSC-based personalized medicine

Personalized medicine aims to provide tailored medical treatment that considers the clinical, genetic, and environmental characteristics of patients. iPSCs have attracted considerable attention in the field of personalized medicine; however, the inherent limitations of iPSCs prevent their widespread...

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Detalles Bibliográficos
Autores principales: Park, Sangbae, Gwon, Yonghyun, Khan, Shahidul Ahmed, Jang, Kyoung-Je, Kim, Jangho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326963/
https://www.ncbi.nlm.nih.gov/pubmed/37420273
http://dx.doi.org/10.1186/s40824-023-00382-x
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author Park, Sangbae
Gwon, Yonghyun
Khan, Shahidul Ahmed
Jang, Kyoung-Je
Kim, Jangho
author_facet Park, Sangbae
Gwon, Yonghyun
Khan, Shahidul Ahmed
Jang, Kyoung-Je
Kim, Jangho
author_sort Park, Sangbae
collection PubMed
description Personalized medicine aims to provide tailored medical treatment that considers the clinical, genetic, and environmental characteristics of patients. iPSCs have attracted considerable attention in the field of personalized medicine; however, the inherent limitations of iPSCs prevent their widespread use in clinical applications. That is, it would be important to develop notable engineering strategies to overcome the current limitations of iPSCs. Such engineering approaches could lead to significant advances in iPSC-based personalized therapy by offering innovative solutions to existing challenges, from iPSC preparation to clinical applications. In this review, we summarize how engineering strategies have been used to advance iPSC-based personalized medicine by categorizing the development process into three distinctive steps: 1) the production of therapeutic iPSCs; 2) engineering of therapeutic iPSCs; and 3) clinical applications of engineered iPSCs. Specifically, we focus on engineering strategies and their implications for each step in the development of iPSC-based personalized medicine.
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spelling pubmed-103269632023-07-08 Engineering considerations of iPSC-based personalized medicine Park, Sangbae Gwon, Yonghyun Khan, Shahidul Ahmed Jang, Kyoung-Je Kim, Jangho Biomater Res Review Personalized medicine aims to provide tailored medical treatment that considers the clinical, genetic, and environmental characteristics of patients. iPSCs have attracted considerable attention in the field of personalized medicine; however, the inherent limitations of iPSCs prevent their widespread use in clinical applications. That is, it would be important to develop notable engineering strategies to overcome the current limitations of iPSCs. Such engineering approaches could lead to significant advances in iPSC-based personalized therapy by offering innovative solutions to existing challenges, from iPSC preparation to clinical applications. In this review, we summarize how engineering strategies have been used to advance iPSC-based personalized medicine by categorizing the development process into three distinctive steps: 1) the production of therapeutic iPSCs; 2) engineering of therapeutic iPSCs; and 3) clinical applications of engineered iPSCs. Specifically, we focus on engineering strategies and their implications for each step in the development of iPSC-based personalized medicine. BioMed Central 2023-07-07 /pmc/articles/PMC10326963/ /pubmed/37420273 http://dx.doi.org/10.1186/s40824-023-00382-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Park, Sangbae
Gwon, Yonghyun
Khan, Shahidul Ahmed
Jang, Kyoung-Je
Kim, Jangho
Engineering considerations of iPSC-based personalized medicine
title Engineering considerations of iPSC-based personalized medicine
title_full Engineering considerations of iPSC-based personalized medicine
title_fullStr Engineering considerations of iPSC-based personalized medicine
title_full_unstemmed Engineering considerations of iPSC-based personalized medicine
title_short Engineering considerations of iPSC-based personalized medicine
title_sort engineering considerations of ipsc-based personalized medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326963/
https://www.ncbi.nlm.nih.gov/pubmed/37420273
http://dx.doi.org/10.1186/s40824-023-00382-x
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