Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects

Bulk tissue molecular quantitative trait loci (QTLs) have been the starting point for interpreting disease-associated variants, while context-specific QTLs show particular relevance for disease. Here, we present the results of mapping interaction QTLs (iQTLs) for cell type, age, and other phenotypic...

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Detalles Bibliográficos
Autores principales: Kasela, Silva, Aguet, François, Kim-Hellmuth, Sarah, Brown, Brielin C., Nachun, Daniel C., Tracy, Russell P., Durda, Peter, Liu, Yongmei, Taylor, Kent D., Craig Johnson, W., Berg, David Van Den, Gabriel, Stacey, Gupta, Namrata, Smith, Joshua D., Blackwell, Thomas W., Rotter, Jerome I., Ardlie, Kristin G., Manichaikul, Ani, Rich, Stephen S., Graham Barr, R., Lappalainen, Tuuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326995/
https://www.ncbi.nlm.nih.gov/pubmed/37425716
http://dx.doi.org/10.1101/2023.06.26.546528

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