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Delayed primacy recall performance predicts post mortem Alzheimer’s disease pathology from unimpaired ante mortem cognitive baseline

INTRODUCTION: We propose a novel method to assess delayed primacy in the CERAD memory test. We then examine whether this measure predicts post mortem Alzheimer’s disease (AD) neuropathology in individuals who were clinically unimpaired at baseline. METHODS: A total of 1096 individuals were selected...

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Autores principales: Bruno, Davide, Gicas, Kristina M., Jauregi Zinkunegi, Ainara, Mueller, Kimberly D., Lamar, Melissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327046/
https://www.ncbi.nlm.nih.gov/pubmed/37425732
http://dx.doi.org/10.1101/2023.06.26.546225
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author Bruno, Davide
Gicas, Kristina M.
Jauregi Zinkunegi, Ainara
Mueller, Kimberly D.
Lamar, Melissa
author_facet Bruno, Davide
Gicas, Kristina M.
Jauregi Zinkunegi, Ainara
Mueller, Kimberly D.
Lamar, Melissa
author_sort Bruno, Davide
collection PubMed
description INTRODUCTION: We propose a novel method to assess delayed primacy in the CERAD memory test. We then examine whether this measure predicts post mortem Alzheimer’s disease (AD) neuropathology in individuals who were clinically unimpaired at baseline. METHODS: A total of 1096 individuals were selected from the Rush Alzheimer’s Disease Center database registry. All participants were clinically unimpaired at baseline, and had subsequently undergone brain autopsy. Average age at baseline was 78.8 (6.92). A Bayesian regression analysis was carried out with global pathology as outcome; demographic, clinical and APOE data as covariates; and cognitive predictors, including delayed primacy. RESULTS: Global AD pathology was best predicted by delayed primacy. Secondary analyses showed that delayed primacy was mostly associated with neuritic plaques, whereas total delayed recall was associated with neurofibrillary tangles. DISCUSSION: We conclude that CERAD-derived delayed primacy is a useful metric for early detection and diagnosis of AD in unimpaired individuals.
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spelling pubmed-103270462023-07-08 Delayed primacy recall performance predicts post mortem Alzheimer’s disease pathology from unimpaired ante mortem cognitive baseline Bruno, Davide Gicas, Kristina M. Jauregi Zinkunegi, Ainara Mueller, Kimberly D. Lamar, Melissa bioRxiv Article INTRODUCTION: We propose a novel method to assess delayed primacy in the CERAD memory test. We then examine whether this measure predicts post mortem Alzheimer’s disease (AD) neuropathology in individuals who were clinically unimpaired at baseline. METHODS: A total of 1096 individuals were selected from the Rush Alzheimer’s Disease Center database registry. All participants were clinically unimpaired at baseline, and had subsequently undergone brain autopsy. Average age at baseline was 78.8 (6.92). A Bayesian regression analysis was carried out with global pathology as outcome; demographic, clinical and APOE data as covariates; and cognitive predictors, including delayed primacy. RESULTS: Global AD pathology was best predicted by delayed primacy. Secondary analyses showed that delayed primacy was mostly associated with neuritic plaques, whereas total delayed recall was associated with neurofibrillary tangles. DISCUSSION: We conclude that CERAD-derived delayed primacy is a useful metric for early detection and diagnosis of AD in unimpaired individuals. Cold Spring Harbor Laboratory 2023-06-27 /pmc/articles/PMC10327046/ /pubmed/37425732 http://dx.doi.org/10.1101/2023.06.26.546225 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Bruno, Davide
Gicas, Kristina M.
Jauregi Zinkunegi, Ainara
Mueller, Kimberly D.
Lamar, Melissa
Delayed primacy recall performance predicts post mortem Alzheimer’s disease pathology from unimpaired ante mortem cognitive baseline
title Delayed primacy recall performance predicts post mortem Alzheimer’s disease pathology from unimpaired ante mortem cognitive baseline
title_full Delayed primacy recall performance predicts post mortem Alzheimer’s disease pathology from unimpaired ante mortem cognitive baseline
title_fullStr Delayed primacy recall performance predicts post mortem Alzheimer’s disease pathology from unimpaired ante mortem cognitive baseline
title_full_unstemmed Delayed primacy recall performance predicts post mortem Alzheimer’s disease pathology from unimpaired ante mortem cognitive baseline
title_short Delayed primacy recall performance predicts post mortem Alzheimer’s disease pathology from unimpaired ante mortem cognitive baseline
title_sort delayed primacy recall performance predicts post mortem alzheimer’s disease pathology from unimpaired ante mortem cognitive baseline
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327046/
https://www.ncbi.nlm.nih.gov/pubmed/37425732
http://dx.doi.org/10.1101/2023.06.26.546225
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