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In vivo magnetic recording of single-neuron action potentials

Measuring fast neuronal signals is the domain of electrophysiology and magnetophysiology. While electrophysiology is much easier to perform, magnetophysiology avoids tissue-based distortions and measures a signal with directional information. At the macroscale, magnetoencephalography (MEG) is establ...

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Autores principales: Klein, Frederike J., Jendritza, Patrick, Chopin, Chloé, Parto-Dezfouli, Mohsen, Solignac, Aurélie, Fermon, Claude, Pannetier-Lecoeur, Myriam, Fries, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327056/
https://www.ncbi.nlm.nih.gov/pubmed/37425851
http://dx.doi.org/10.1101/2023.06.30.547194
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author Klein, Frederike J.
Jendritza, Patrick
Chopin, Chloé
Parto-Dezfouli, Mohsen
Solignac, Aurélie
Fermon, Claude
Pannetier-Lecoeur, Myriam
Fries, Pascal
author_facet Klein, Frederike J.
Jendritza, Patrick
Chopin, Chloé
Parto-Dezfouli, Mohsen
Solignac, Aurélie
Fermon, Claude
Pannetier-Lecoeur, Myriam
Fries, Pascal
author_sort Klein, Frederike J.
collection PubMed
description Measuring fast neuronal signals is the domain of electrophysiology and magnetophysiology. While electrophysiology is much easier to perform, magnetophysiology avoids tissue-based distortions and measures a signal with directional information. At the macroscale, magnetoencephalography (MEG) is established, and at the mesoscale, visually evoked magnetic fields have been reported. At the microscale however, while benefits of recording magnetic counterparts of electric spikes would be numerous, they are also highly challenging in vivo. Here, we combine magnetic and electric recordings of neuronal action potentials in anesthetized rats using miniaturized giant magneto-resistance (GMR) sensors. We reveal the magnetic signature of action potentials of well isolated single units. The recorded magnetic signals showed a distinct waveform and considerable signal strength. This demonstration of in vivo magnetic action potentials opens a wide field of possibilities to profit from the combined power of magnetic and electric recordings and thus to significantly advance the understanding of neuronal circuits.
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spelling pubmed-103270562023-07-08 In vivo magnetic recording of single-neuron action potentials Klein, Frederike J. Jendritza, Patrick Chopin, Chloé Parto-Dezfouli, Mohsen Solignac, Aurélie Fermon, Claude Pannetier-Lecoeur, Myriam Fries, Pascal bioRxiv Article Measuring fast neuronal signals is the domain of electrophysiology and magnetophysiology. While electrophysiology is much easier to perform, magnetophysiology avoids tissue-based distortions and measures a signal with directional information. At the macroscale, magnetoencephalography (MEG) is established, and at the mesoscale, visually evoked magnetic fields have been reported. At the microscale however, while benefits of recording magnetic counterparts of electric spikes would be numerous, they are also highly challenging in vivo. Here, we combine magnetic and electric recordings of neuronal action potentials in anesthetized rats using miniaturized giant magneto-resistance (GMR) sensors. We reveal the magnetic signature of action potentials of well isolated single units. The recorded magnetic signals showed a distinct waveform and considerable signal strength. This demonstration of in vivo magnetic action potentials opens a wide field of possibilities to profit from the combined power of magnetic and electric recordings and thus to significantly advance the understanding of neuronal circuits. Cold Spring Harbor Laboratory 2023-07-02 /pmc/articles/PMC10327056/ /pubmed/37425851 http://dx.doi.org/10.1101/2023.06.30.547194 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Klein, Frederike J.
Jendritza, Patrick
Chopin, Chloé
Parto-Dezfouli, Mohsen
Solignac, Aurélie
Fermon, Claude
Pannetier-Lecoeur, Myriam
Fries, Pascal
In vivo magnetic recording of single-neuron action potentials
title In vivo magnetic recording of single-neuron action potentials
title_full In vivo magnetic recording of single-neuron action potentials
title_fullStr In vivo magnetic recording of single-neuron action potentials
title_full_unstemmed In vivo magnetic recording of single-neuron action potentials
title_short In vivo magnetic recording of single-neuron action potentials
title_sort in vivo magnetic recording of single-neuron action potentials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327056/
https://www.ncbi.nlm.nih.gov/pubmed/37425851
http://dx.doi.org/10.1101/2023.06.30.547194
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