Cargando…
In vivo magnetic recording of single-neuron action potentials
Measuring fast neuronal signals is the domain of electrophysiology and magnetophysiology. While electrophysiology is much easier to perform, magnetophysiology avoids tissue-based distortions and measures a signal with directional information. At the macroscale, magnetoencephalography (MEG) is establ...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327056/ https://www.ncbi.nlm.nih.gov/pubmed/37425851 http://dx.doi.org/10.1101/2023.06.30.547194 |
_version_ | 1785069549580713984 |
---|---|
author | Klein, Frederike J. Jendritza, Patrick Chopin, Chloé Parto-Dezfouli, Mohsen Solignac, Aurélie Fermon, Claude Pannetier-Lecoeur, Myriam Fries, Pascal |
author_facet | Klein, Frederike J. Jendritza, Patrick Chopin, Chloé Parto-Dezfouli, Mohsen Solignac, Aurélie Fermon, Claude Pannetier-Lecoeur, Myriam Fries, Pascal |
author_sort | Klein, Frederike J. |
collection | PubMed |
description | Measuring fast neuronal signals is the domain of electrophysiology and magnetophysiology. While electrophysiology is much easier to perform, magnetophysiology avoids tissue-based distortions and measures a signal with directional information. At the macroscale, magnetoencephalography (MEG) is established, and at the mesoscale, visually evoked magnetic fields have been reported. At the microscale however, while benefits of recording magnetic counterparts of electric spikes would be numerous, they are also highly challenging in vivo. Here, we combine magnetic and electric recordings of neuronal action potentials in anesthetized rats using miniaturized giant magneto-resistance (GMR) sensors. We reveal the magnetic signature of action potentials of well isolated single units. The recorded magnetic signals showed a distinct waveform and considerable signal strength. This demonstration of in vivo magnetic action potentials opens a wide field of possibilities to profit from the combined power of magnetic and electric recordings and thus to significantly advance the understanding of neuronal circuits. |
format | Online Article Text |
id | pubmed-10327056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-103270562023-07-08 In vivo magnetic recording of single-neuron action potentials Klein, Frederike J. Jendritza, Patrick Chopin, Chloé Parto-Dezfouli, Mohsen Solignac, Aurélie Fermon, Claude Pannetier-Lecoeur, Myriam Fries, Pascal bioRxiv Article Measuring fast neuronal signals is the domain of electrophysiology and magnetophysiology. While electrophysiology is much easier to perform, magnetophysiology avoids tissue-based distortions and measures a signal with directional information. At the macroscale, magnetoencephalography (MEG) is established, and at the mesoscale, visually evoked magnetic fields have been reported. At the microscale however, while benefits of recording magnetic counterparts of electric spikes would be numerous, they are also highly challenging in vivo. Here, we combine magnetic and electric recordings of neuronal action potentials in anesthetized rats using miniaturized giant magneto-resistance (GMR) sensors. We reveal the magnetic signature of action potentials of well isolated single units. The recorded magnetic signals showed a distinct waveform and considerable signal strength. This demonstration of in vivo magnetic action potentials opens a wide field of possibilities to profit from the combined power of magnetic and electric recordings and thus to significantly advance the understanding of neuronal circuits. Cold Spring Harbor Laboratory 2023-07-02 /pmc/articles/PMC10327056/ /pubmed/37425851 http://dx.doi.org/10.1101/2023.06.30.547194 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. |
spellingShingle | Article Klein, Frederike J. Jendritza, Patrick Chopin, Chloé Parto-Dezfouli, Mohsen Solignac, Aurélie Fermon, Claude Pannetier-Lecoeur, Myriam Fries, Pascal In vivo magnetic recording of single-neuron action potentials |
title | In vivo magnetic recording of single-neuron action potentials |
title_full | In vivo magnetic recording of single-neuron action potentials |
title_fullStr | In vivo magnetic recording of single-neuron action potentials |
title_full_unstemmed | In vivo magnetic recording of single-neuron action potentials |
title_short | In vivo magnetic recording of single-neuron action potentials |
title_sort | in vivo magnetic recording of single-neuron action potentials |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327056/ https://www.ncbi.nlm.nih.gov/pubmed/37425851 http://dx.doi.org/10.1101/2023.06.30.547194 |
work_keys_str_mv | AT kleinfrederikej invivomagneticrecordingofsingleneuronactionpotentials AT jendritzapatrick invivomagneticrecordingofsingleneuronactionpotentials AT chopinchloe invivomagneticrecordingofsingleneuronactionpotentials AT partodezfoulimohsen invivomagneticrecordingofsingleneuronactionpotentials AT solignacaurelie invivomagneticrecordingofsingleneuronactionpotentials AT fermonclaude invivomagneticrecordingofsingleneuronactionpotentials AT pannetierlecoeurmyriam invivomagneticrecordingofsingleneuronactionpotentials AT friespascal invivomagneticrecordingofsingleneuronactionpotentials |