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Sex difference in the facilitation of fear learning by prior fear conditioning
There is now ample evidence that the strength and underlying mechanisms of memory formation can be drastically altered by prior experience. However, the prior work using rodent models on this topic has used only males as subjects, and as a result, we do know whether or not the effects of prior exper...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327064/ https://www.ncbi.nlm.nih.gov/pubmed/37425868 http://dx.doi.org/10.1101/2023.06.29.547102 |
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author | Cole, Kehinde E. Parsons, Ryan G. |
author_facet | Cole, Kehinde E. Parsons, Ryan G. |
author_sort | Cole, Kehinde E. |
collection | PubMed |
description | There is now ample evidence that the strength and underlying mechanisms of memory formation can be drastically altered by prior experience. However, the prior work using rodent models on this topic has used only males as subjects, and as a result, we do know whether or not the effects of prior experience on subsequent learning are similar in both sexes. As a first step towards addressing this shortcoming rats of both sexes were given auditory fear conditioning, or fear conditioning with unsignaled shocks, followed an hour or a day later by a single pairing of light and shock. Fear memory for each experience was assessed by measuring freezing behavior to the auditory cue and fear-potentiated startle to the light. Results showed that males trained with auditory fear conditioning showed facilitated learning to the subsequent visual fear conditioning session when the two training sessions were separated by one hour or one day. Females showed evidence of facilitation in rats given auditory conditioning when they were spaced by an hour, but not when they were spaced by one day. Contextual fear conditioning did not support the facilitation of subsequent learning under any conditions. These results indicate that the mechanism by which prior fear conditioning facilitates subsequent learning differs between sexes, and they set the stage for mechanistic studies to understand the neurobiological basis of this sex difference. |
format | Online Article Text |
id | pubmed-10327064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-103270642023-07-08 Sex difference in the facilitation of fear learning by prior fear conditioning Cole, Kehinde E. Parsons, Ryan G. bioRxiv Article There is now ample evidence that the strength and underlying mechanisms of memory formation can be drastically altered by prior experience. However, the prior work using rodent models on this topic has used only males as subjects, and as a result, we do know whether or not the effects of prior experience on subsequent learning are similar in both sexes. As a first step towards addressing this shortcoming rats of both sexes were given auditory fear conditioning, or fear conditioning with unsignaled shocks, followed an hour or a day later by a single pairing of light and shock. Fear memory for each experience was assessed by measuring freezing behavior to the auditory cue and fear-potentiated startle to the light. Results showed that males trained with auditory fear conditioning showed facilitated learning to the subsequent visual fear conditioning session when the two training sessions were separated by one hour or one day. Females showed evidence of facilitation in rats given auditory conditioning when they were spaced by an hour, but not when they were spaced by one day. Contextual fear conditioning did not support the facilitation of subsequent learning under any conditions. These results indicate that the mechanism by which prior fear conditioning facilitates subsequent learning differs between sexes, and they set the stage for mechanistic studies to understand the neurobiological basis of this sex difference. Cold Spring Harbor Laboratory 2023-06-30 /pmc/articles/PMC10327064/ /pubmed/37425868 http://dx.doi.org/10.1101/2023.06.29.547102 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Cole, Kehinde E. Parsons, Ryan G. Sex difference in the facilitation of fear learning by prior fear conditioning |
title | Sex difference in the facilitation of fear learning by prior fear conditioning |
title_full | Sex difference in the facilitation of fear learning by prior fear conditioning |
title_fullStr | Sex difference in the facilitation of fear learning by prior fear conditioning |
title_full_unstemmed | Sex difference in the facilitation of fear learning by prior fear conditioning |
title_short | Sex difference in the facilitation of fear learning by prior fear conditioning |
title_sort | sex difference in the facilitation of fear learning by prior fear conditioning |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327064/ https://www.ncbi.nlm.nih.gov/pubmed/37425868 http://dx.doi.org/10.1101/2023.06.29.547102 |
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