p53-Bad* in a Hepatocellular Carcinoma Mouse Model

Recent advances in liver cancer treatments have not changed the fact that the majority of patients will not survive the disease. In order to advance future liver cancer treatments, this work presents an exploration of various iterations of the liver cancer specific AFP promoter as well as the gene c...

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Detalles Bibliográficos
Autores principales: Bowman, Katherine Redd, Lu, Phong, Lim, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327098/
https://www.ncbi.nlm.nih.gov/pubmed/37425886
http://dx.doi.org/10.1101/2023.06.29.547129
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author Bowman, Katherine Redd
Lu, Phong
Lim, Carol
author_facet Bowman, Katherine Redd
Lu, Phong
Lim, Carol
author_sort Bowman, Katherine Redd
collection PubMed
description Recent advances in liver cancer treatments have not changed the fact that the majority of patients will not survive the disease. In order to advance future liver cancer treatments, this work presents an exploration of various iterations of the liver cancer specific AFP promoter as well as the gene construct p53-Bad*. p53-Bad* is a mitochondrially targeted re-engineered p53 therapy that has shown previous success in a zebrafish HCC model. Both the most promising AFP promoter and p53-Bad* were packaged in an adenoviral delivery system and tested in vitro in liver cancer cell lines. Finally, mixed results for adenoviral p53-Bad* in vivo are presented, and this work suggests future modifications to study parameters in order to further explore the potential of p53-Bad* as a potential liver cancer therapeutic.
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spelling pubmed-103270982023-07-08 p53-Bad* in a Hepatocellular Carcinoma Mouse Model Bowman, Katherine Redd Lu, Phong Lim, Carol bioRxiv Article Recent advances in liver cancer treatments have not changed the fact that the majority of patients will not survive the disease. In order to advance future liver cancer treatments, this work presents an exploration of various iterations of the liver cancer specific AFP promoter as well as the gene construct p53-Bad*. p53-Bad* is a mitochondrially targeted re-engineered p53 therapy that has shown previous success in a zebrafish HCC model. Both the most promising AFP promoter and p53-Bad* were packaged in an adenoviral delivery system and tested in vitro in liver cancer cell lines. Finally, mixed results for adenoviral p53-Bad* in vivo are presented, and this work suggests future modifications to study parameters in order to further explore the potential of p53-Bad* as a potential liver cancer therapeutic. Cold Spring Harbor Laboratory 2023-06-29 /pmc/articles/PMC10327098/ /pubmed/37425886 http://dx.doi.org/10.1101/2023.06.29.547129 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Bowman, Katherine Redd
Lu, Phong
Lim, Carol
p53-Bad* in a Hepatocellular Carcinoma Mouse Model
title p53-Bad* in a Hepatocellular Carcinoma Mouse Model
title_full p53-Bad* in a Hepatocellular Carcinoma Mouse Model
title_fullStr p53-Bad* in a Hepatocellular Carcinoma Mouse Model
title_full_unstemmed p53-Bad* in a Hepatocellular Carcinoma Mouse Model
title_short p53-Bad* in a Hepatocellular Carcinoma Mouse Model
title_sort p53-bad* in a hepatocellular carcinoma mouse model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327098/
https://www.ncbi.nlm.nih.gov/pubmed/37425886
http://dx.doi.org/10.1101/2023.06.29.547129
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