Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis

In combination with cell intrinsic properties, interactions in the tumor microenvironment modulate therapeutic response. We leveraged high-plex single-cell spatial transcriptomics to dissect the remodeling of multicellular neighborhoods and cell–cell interactions in human pancreatic cancer associate...

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Detalles Bibliográficos
Autores principales: Shiau, Carina, Cao, Jingyi, Gregory, Mark T., Gong, Dennis, Yin, Xunqin, Cho, Jae-Won, Wang, Peter L., Su, Jennifer, Wang, Steven, Reeves, Jason W., Kim, Tae Kyung, Kim, Youngmi, Guo, Jimmy A., Lester, Nicole A., Schurman, Nathan, Barth, Jamie L., Weissleder, Ralph, Jacks, Tyler, Qadan, Motaz, Hong, Theodore S., Wo, Jennifer Y., Roberts, Hannah, Beechem, Joseph M., Castillo, Carlos Fernandez-del, Mino-Kenudson, Mari, Ting, David T., Hemberg, Martin, Hwang, William L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327107/
https://www.ncbi.nlm.nih.gov/pubmed/37425692
http://dx.doi.org/10.1101/2023.06.28.546848

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