Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING(A230) Variants

Previously we identified a non-nucleotide tricyclic agonist BDW568 that activates human STING (stimulator of interferon genes) gene variant containing A230 in a human monocyte cell line (THP-1). STING(A230) alleles, including HAQ and AQ, are less common STING variants in human population. To further...

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Detalles Bibliográficos
Autores principales: Tang, Zhichao, Zhao, Junxing, Li, Ying, Tomer, Shallu, Selvaraju, Manikandan, Tien, Nicholas, Sun, Diyun, Johnson, David K., Zhen, Anjie, Li, Pingwei, Wang, Jingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327114/
https://www.ncbi.nlm.nih.gov/pubmed/37425806
http://dx.doi.org/10.1101/2023.07.02.547363

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