The importance of input sequence set to consensus-derived proteins and their relationship to reconstructed ancestral proteins

A protein sequence encodes its energy landscape - all the accessible conformations, energetics, and dynamics. The evolutionary relationship between sequence and landscape can be probed phylogenetically by compiling a multiple sequence alignment of homologous sequences and generating common ancestors...

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Detalles Bibliográficos
Autores principales: Nixon, Charlotte, Lim, Shion A., Sternke, Matt, Barrick, Doug, Harms, Mike, Marqusee, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327145/
https://www.ncbi.nlm.nih.gov/pubmed/37425932
http://dx.doi.org/10.1101/2023.06.29.547063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327145/
https://www.ncbi.nlm.nih.gov/pubmed/37425932
http://dx.doi.org/10.1101/2023.06.29.547063

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