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The importance of input sequence set to consensus-derived proteins and their relationship to reconstructed ancestral proteins
A protein sequence encodes its energy landscape - all the accessible conformations, energetics, and dynamics. The evolutionary relationship between sequence and landscape can be probed phylogenetically by compiling a multiple sequence alignment of homologous sequences and generating common ancestors...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327145/ https://www.ncbi.nlm.nih.gov/pubmed/37425932 http://dx.doi.org/10.1101/2023.06.29.547063 |