Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation

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Huntington’s disease arises from a toxic gain of function in the huntingtin (HTT) gene. As a result, many HTT-lowering therapies are being pursued in clinical studies, including those that reduce HTT RNA and protein expression in the liver. To investigate potential impacts, we characterized molecula...

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Detalles Bibliográficos
Autores principales: Bragg, Robert M., Coffey, Sydney R., Cantle, Jeffrey P., Hu, Shikai, Singh, Sucha, Legg, Samuel R.W., McHugh, Cassandra A., Toor, Amreen, Zeitlin, Scott O., Kwak, Seung, Howland, David, Vogt, Thomas F., Monga, Satdarshan P., Carroll, Jeffrey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327156/
https://www.ncbi.nlm.nih.gov/pubmed/37425835
http://dx.doi.org/10.1101/2023.06.24.546334

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