Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

RAC1(P29S) is the third most prevalent hotspot mutation in sun-exposed melanoma. RAC1 alterations in cancer are correlated with poor prognosis, resistance to standard chemotherapy, and insensitivity to targeted inhibitors. Although RAC1(P29S) mutations in melanoma and RAC1 alterations in several oth...

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Detalles Bibliográficos
Autores principales: Cannon, Alexa C., Budagyan, Konstantin, Uribe-Alvarez, Cristina, Kurimchak, Alison M., Araiza-Olivera, Daniela, Cai, Kathy Q., Peri, Suraj, Zhou, Yan, Duncan, James S., Chernoff, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327161/
https://www.ncbi.nlm.nih.gov/pubmed/37425776
http://dx.doi.org/10.1101/2023.06.27.546707

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