Inflammatory macrophages prevent colonic goblet and enteroendocrine cell differentiation through Notch signaling

Inflammatory macrophages in the intestine are a key pathogenic factor driving inflammatory bowel disease (IBD). Here, we report the role of inflammatory macrophage-mediated notch signaling on secretory lineage differentiation in the intestinal epithelium. Utilizing IL-10-deficient (Il10(−/−)) mice,...

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Detalles Bibliográficos
Autores principales: Atanga, Roger, Romero, Aaron S., Hernandez, Anthony Jimenez, Peralta-Herrera, Eduardo, Merkley, Seth D., In, Julie G., Castillo, Eliseo F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327198/
https://www.ncbi.nlm.nih.gov/pubmed/37425818
http://dx.doi.org/10.1101/2023.06.29.547119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327198/
https://www.ncbi.nlm.nih.gov/pubmed/37425818
http://dx.doi.org/10.1101/2023.06.29.547119

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