Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail

Cofilin family proteins have essential roles in remodeling the cytoskeleton through filamentous actin depolymerization and severing. The short unstructured N-terminal region of cofilin is critical for actin binding and harbors the major site of inhibitory phosphorylation. Atypically for a disordered...

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Detalles Bibliográficos
Autores principales: Sexton, Joel A., Potchernikov, Tony, Bibeau, Jeffrey P., Casanova-Sepúlveda, Gabriela, Cao, Wenxiang, Lou, Hua Jane, Boggon, Titus J., De La Cruz, Enrique M., Turk, Benjamin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327202/
https://www.ncbi.nlm.nih.gov/pubmed/37425676
http://dx.doi.org/10.1101/2023.06.30.547189

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