Genetically-regulated pathway-polygenic risk score (GRPa-PRS): A risk stratification method to identify genetically regulated pathways in polygenic diseases

BACKGROUND: Alzheimer’s disease (AD) is a common neurodegenerative disease in the elderly population, with genetic factors playing an important role. A considerable proportion of elderly people carry a high genetic AD risk but evade AD. On the other hand, some individuals with a low risk for AD even...

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Detalles Bibliográficos
Autores principales: Li, Xiaoyang, Fernandes, Brisa S., Liu, Andi, Lu, Yimei, Chen, Jingchun, Zhao, Zhongming, Dai, Yulin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327215/
https://www.ncbi.nlm.nih.gov/pubmed/37425929
http://dx.doi.org/10.1101/2023.06.19.23291621

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