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Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography

Corneal collagen crosslinking (CXL) is commonly used to prevent or treat keratoconus. Although changes in corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic optical coherence elastography (OCE) by tracking mechanical wave propagation, depth dependent changes are still...

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Autores principales: Regnault, Gabriel, Kirby, Mitchell A., Wang, Ruikang K., Shen, Tueng T., O’Donnell, Matthew, Pelivanov, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cornell University 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327230/
https://www.ncbi.nlm.nih.gov/pubmed/37426451
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author Regnault, Gabriel
Kirby, Mitchell A.
Wang, Ruikang K.
Shen, Tueng T.
O’Donnell, Matthew
Pelivanov, Ivan
author_facet Regnault, Gabriel
Kirby, Mitchell A.
Wang, Ruikang K.
Shen, Tueng T.
O’Donnell, Matthew
Pelivanov, Ivan
author_sort Regnault, Gabriel
collection PubMed
description Corneal collagen crosslinking (CXL) is commonly used to prevent or treat keratoconus. Although changes in corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic optical coherence elastography (OCE) by tracking mechanical wave propagation, depth dependent changes are still unclear if the cornea is not crosslinked through the whole depth. Here, phase-decorrelation measurements on optical coherence tomography (OCT) structural images are combined with acoustic micro-tapping (AμT) OCE to explore possible reconstruction of depth-dependent stiffness within crosslinked corneas in an ex vivo human cornea sample. Experimental OCT images are analyzed to define the penetration depth of CXL into the cornea. In a representative ex vivo human cornea sample, crosslinking depth varied from ~ 100 μm in the periphery to ~ 150 μm in the cornea center and exhibited a sharp in-depth transition between crosslinked and untreated areas. This information was used in an analytical two-layer guided wave propagation model to quantify the stiffness of the treated layer. We also discuss how the elastic moduli of partially CXL-treated cornea layers reflect the effective engineering stiffness of the entire cornea to properly quantify corneal deformation.
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spelling pubmed-103272302023-07-08 Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography Regnault, Gabriel Kirby, Mitchell A. Wang, Ruikang K. Shen, Tueng T. O’Donnell, Matthew Pelivanov, Ivan ArXiv Article Corneal collagen crosslinking (CXL) is commonly used to prevent or treat keratoconus. Although changes in corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic optical coherence elastography (OCE) by tracking mechanical wave propagation, depth dependent changes are still unclear if the cornea is not crosslinked through the whole depth. Here, phase-decorrelation measurements on optical coherence tomography (OCT) structural images are combined with acoustic micro-tapping (AμT) OCE to explore possible reconstruction of depth-dependent stiffness within crosslinked corneas in an ex vivo human cornea sample. Experimental OCT images are analyzed to define the penetration depth of CXL into the cornea. In a representative ex vivo human cornea sample, crosslinking depth varied from ~ 100 μm in the periphery to ~ 150 μm in the cornea center and exhibited a sharp in-depth transition between crosslinked and untreated areas. This information was used in an analytical two-layer guided wave propagation model to quantify the stiffness of the treated layer. We also discuss how the elastic moduli of partially CXL-treated cornea layers reflect the effective engineering stiffness of the entire cornea to properly quantify corneal deformation. Cornell University 2023-06-26 /pmc/articles/PMC10327230/ /pubmed/37426451 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Regnault, Gabriel
Kirby, Mitchell A.
Wang, Ruikang K.
Shen, Tueng T.
O’Donnell, Matthew
Pelivanov, Ivan
Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography
title Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography
title_full Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography
title_fullStr Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography
title_full_unstemmed Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography
title_short Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography
title_sort possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (cxl) with optical coherence tomography and elastography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327230/
https://www.ncbi.nlm.nih.gov/pubmed/37426451
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